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Tnc tenascin C [ Mus musculus (house mouse) ]

Gene ID: 21923, updated on 2-Apr-2024

Summary

Official Symbol
Tncprovided by MGI
Official Full Name
tenascin Cprovided by MGI
Primary source
MGI:MGI:101922
See related
Ensembl:ENSMUSG00000028364 AllianceGenome:MGI:101922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik
Summary
Predicted to enable fibronectin binding activity and syndecan binding activity. Acts upstream of or within several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and prostate gland development. Located in collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; brain; immune system; ovary; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 49.7), bladder adult (RPKM 28.6) and 15 other tissues See more
Orthologs
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Genomic context

See Tnc in Genome Data Viewer
Location:
4 C1; 4 34.06 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63878022..63965554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63959785..64047015, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10447 Neighboring gene tumor necrosis factor (ligand) superfamily, member 8 Neighboring gene ribosomal protein L17, pseudogene 4 Neighboring gene RIKEN cDNA 8030451A03 gene Neighboring gene STARR-seq mESC enhancer starr_10448 Neighboring gene STARR-seq mESC enhancer starr_10449 Neighboring gene predicted gene, 31115 Neighboring gene STARR-seq mESC enhancer starr_10450 Neighboring gene STARR-seq mESC enhancer starr_10451 Neighboring gene predicted gene 11217 Neighboring gene STARR-seq mESC enhancer starr_10452 Neighboring gene STARR-seq mESC enhancer starr_10453 Neighboring gene STARR-seq mESC enhancer starr_10454 Neighboring gene predicted gene, 23950

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC144208, MGC144209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in bud outgrowth involved in lung branching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peripheral nervous system axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tenascin
Names
hexabrachion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369211.1NP_001356140.1  tenascin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL732556
    Consensus CDS
    CCDS89763.1
    UniProtKB/Swiss-Prot
    Q64706, Q80YX1, Q80YX2
    Related
    ENSMUSP00000102995.2, ENSMUST00000107372.8
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:18892098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408434
    EGF_2; EGF-like domain
    pfam00041
    Location:894976
    fn3; Fibronectin type III domain
  2. NM_001369212.1NP_001356141.1  tenascin isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732556
    UniProtKB/TrEMBL
    Q148T4
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:17071916
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408434
    EGF_2; EGF-like domain
    pfam00041
    Location:894976
    fn3; Fibronectin type III domain
  3. NM_001369213.1NP_001356142.1  tenascin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732556
    Conserved Domains (4) summary
    cd00063
    Location:363449
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:15371746
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:147173
    EGF_2; EGF-like domain
    pfam00041
    Location:633715
    fn3; Fibronectin type III domain
  4. NM_001369214.1NP_001356143.1  tenascin isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732556
    UniProtKB/TrEMBL
    Q148T4, Q148T5
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:13431552
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408434
    EGF_2; EGF-like domain
    pfam00041
    Location:894976
    fn3; Fibronectin type III domain
  5. NM_011607.3NP_035737.2  tenascin isoform 2 precursor

    See identical proteins and their annotated locations for NP_035737.2

    Status: VALIDATED

    Source sequence(s)
    AK040167, AL732556, BC117979, BY300535, CN664449
    Consensus CDS
    CCDS18265.1
    UniProtKB/Swiss-Prot
    Q80YX1
    UniProtKB/TrEMBL
    Q148T5, Q8C9Z1
    Related
    ENSMUSP00000103000.4, ENSMUST00000107377.10
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:894976
    fn3; Fibronectin type III domain
    pfam00147
    Location:17982007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408434
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63878022..63965554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537776.2XP_006537839.1  tenascin isoform X1

    UniProtKB/TrEMBL
    Q148T4
    Conserved Domains (6) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:14341643
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:345372
    EGF_2; EGF-like domain
    pfam00041
    Location:894976
    fn3; Fibronectin type III domain
    pfam01414
    Location:516558
    DSL; Delta serrate ligand
    pfam18720
    Location:408435
    EGF_Tenascin; Tenascin EGF domain