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TNC tenascin C [ Homo sapiens (human) ]

Gene ID: 3371, updated on 17-Nov-2018

Summary

Official Symbol
TNCprovided by HGNC
Official Full Name
tenascin Cprovided by HGNC
Primary source
HGNC:HGNC:5318
See related
Ensembl:ENSG00000041982 MIM:187380; Vega:OTTHUMG00000021010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
Summary
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Expression
Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues See more
Orthologs

Genomic context

See TNC in Genome Data Viewer
Location:
9q33.1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (115019575..115118257, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117781854..117880536, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 4B pseudogene Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC101928748 Neighboring gene deleted in esophageal cancer 1 Neighboring gene uncharacterized LOC105376233

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Deafness, autosomal dominant 56
MedGen: C3810170 OMIM: 615629 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 is inhibited by TNC (tenascin C), MUC1, and LTF (lactoferrin) as shown through neutralization assays in TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
Envelope surface glycoprotein gp160, precursor env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tenascin C (TNC) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystem (from WikiPathways)
    Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystemThis pathway is based on Figure 4 of "Origins of metastatic traits."(See Bibliography).The majority of cancer cells released from tumors die off, so cancer biologists are trying to figure out exactly...
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Syndecan interactions, organism-specific biosystem (from REACTOME)
    Syndecan interactions, organism-specific biosystemSyndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. ...
  • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-4-mediated signaling events, organism-specific biosystem
    Syndecan-4-mediated signaling events
  • TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystem (from WikiPathways)
    TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystemThis pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-? Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TG...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC167029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent HDA PubMed 
extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syndecan binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bud outgrowth involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to prostaglandin D stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
mesenchymal-epithelial cell signaling involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation HDA PubMed 
peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
prostate gland epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to fibroblast growth factor IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tenascin
Names
GP 150-225
cytotactin
deafness, autosomal dominant 56
glioma-associated-extracellular matrix antigen
hexabrachion (tenascin)
myotendinous antigen
neuronectin
tenascin-C additional domain 1
tenascin-C isoform 14/AD1/16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029637.1 RefSeqGene

    Range
    5001..103683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002160.3NP_002151.2  tenascin precursor

    Status: REVIEWED

    Source sequence(s)
    AB210038, AI266750, AI964017, AK304015, BP279008, BU860660, BX100095, X78565
    Consensus CDS
    CCDS6811.1
    UniProtKB/Swiss-Prot
    P24821
    UniProtKB/TrEMBL
    B4E1W8, Q4LE33
    Related
    ENSP00000265131.4, OTTHUMP00000022738, ENST00000350763.8, OTTHUMT00000055418
    Conserved Domains (3) summary
    pfam00147
    Location:19802189
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
    pfam00041
    Location:18881960
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    115019575..115118257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447530.1XP_024303298.1  tenascin isoform X1

    Conserved Domains (3) summary
    pfam00147
    Location:21632372
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
    pfam00041
    Location:20712143
    fn3; Fibronectin type III domain
  2. XM_005251975.4XP_005252032.1  tenascin isoform X16

    UniProtKB/Swiss-Prot
    P24821
    Related
    ENSP00000443478.1, OTTHUMP00000237695, ENST00000537320.5
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:12511323
    fn3; Fibronectin type III domain
    pfam00147
    Location:13431552
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  3. XM_005251974.4XP_005252031.1  tenascin isoform X14

    UniProtKB/Swiss-Prot
    P24821
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:13421414
    fn3; Fibronectin type III domain
    pfam00147
    Location:14341643
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  4. XM_011518629.3XP_011516931.1  tenascin isoform X12

    UniProtKB/Swiss-Prot
    P24821
    Conserved Domains (5) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:14331505
    fn3; Fibronectin type III domain
    pfam00147
    Location:15251734
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
    cl19567
    Location:486527
    DSL; Delta serrate ligand
  5. XM_011518626.3XP_011516928.1  tenascin isoform X10

    Related
    ENSP00000438152.2, ENST00000535648.5
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:16161688
    fn3; Fibronectin type III domain
    pfam00147
    Location:17081917
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  6. XM_017014681.2XP_016870170.1  tenascin isoform X7

  7. XM_006717101.4XP_006717164.1  tenascin isoform X15

    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:13421414
    fn3; Fibronectin type III domain
    pfam00147
    Location:14341643
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  8. XM_011518628.3XP_011516930.1  tenascin isoform X13

    Conserved Domains (5) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:14331505
    fn3; Fibronectin type III domain
    pfam00147
    Location:15251734
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
    cl19567
    Location:486527
    DSL; Delta serrate ligand
  9. XM_006717098.4XP_006717161.1  tenascin isoform X8

    UniProtKB/TrEMBL
    J3QSU6
    Related
    ENSP00000339553.4, OTTHUMP00000237669, ENST00000341037.8
    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:17061778
    fn3; Fibronectin type III domain
    pfam00147
    Location:17982007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  10. XM_006717097.4XP_006717160.1  tenascin isoform X6

    Conserved Domains (3) summary
    pfam00041
    Location:17971869
    fn3; Fibronectin type III domain
    pfam00147
    Location:18892098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  11. XM_017014679.2XP_016870168.1  tenascin isoform X3

  12. XM_005251973.4XP_005252030.1  tenascin isoform X11

    Conserved Domains (4) summary
    cd00063
    Location:624710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:15241596
    fn3; Fibronectin type III domain
    pfam00147
    Location:16161825
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  13. XM_011518625.3XP_011516927.1  tenascin isoform X9

    Related
    ENSP00000411406.2, OTTHUMP00000237658, ENST00000423613.6
    Conserved Domains (3) summary
    pfam00041
    Location:17061778
    fn3; Fibronectin type III domain
    pfam00147
    Location:17982007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  14. XM_005251972.4XP_005252029.1  tenascin isoform X5

    UniProtKB/Swiss-Prot
    P24821
    Conserved Domains (3) summary
    pfam00041
    Location:17971869
    fn3; Fibronectin type III domain
    pfam00147
    Location:18892098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  15. XM_006717096.4XP_006717159.1  tenascin isoform X2

    Conserved Domains (3) summary
    pfam00041
    Location:19802052
    fn3; Fibronectin type III domain
    pfam00147
    Location:20722281
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
  16. XM_017014680.2XP_016870169.1  tenascin isoform X4

  17. XM_017014678.2XP_016870167.1  tenascin isoform X1

    Conserved Domains (3) summary
    pfam00147
    Location:21632372
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:468496
    EGF_2; EGF-like domain
    pfam00041
    Location:20712143
    fn3; Fibronectin type III domain
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