U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tle4 transducin-like enhancer of split 4 [ Mus musculus (house mouse) ]

Gene ID: 21888, updated on 17-Jan-2023

Summary

Official Symbol
Tle4provided by MGI
Official Full Name
transducin-like enhancer of split 4provided by MGI
Primary source
MGI:MGI:104633
See related
Ensembl:ENSMUSG00000024642 AllianceGenome:MGI:104633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bce1; Grg4; Bce-1; grg-4; ESTM13; ESTM14; 5730411M05Rik
Summary
Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and peripheral nervous system ganglion. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 15.3), CNS E18 (RPKM 14.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tle4 in Genome Data Viewer
Location:
19 A; 19 9.11 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (14425436..14575547, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (14448072..14598183, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor enhancer Tinos Neighboring gene predicted gene, 31331 Neighboring gene predicted gene 8630 Neighboring gene predicted gene, 31441 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene ribosomal protein L13 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transducin-like enhancer protein 4
Names
B lymphocyte gene 1
groucho-related protein 4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302947.2NP_001289876.1  transducin-like enhancer protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001289876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122202, AC125315
    UniProtKB/TrEMBL
    A0A6P5P6Q9, Q3UY41
    Conserved Domains (3) summary
    cd00200
    Location:487771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:491530
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:16139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. NM_001302950.2NP_001289879.1  transducin-like enhancer protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001289879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC122202, AC125315
    UniProtKB/TrEMBL
    Q3UY41
    Conserved Domains (3) summary
    cd00200
    Location:462746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:466505
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:16103
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. NM_001302951.2NP_001289880.1  transducin-like enhancer protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, which results in a distinct 5' UTR and use of an alternate start codon, compared to variant 1. The encoded protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC122202, AC125315
    UniProtKB/TrEMBL
    A0A6P5P2S4, Q3UY41
    Conserved Domains (3) summary
    cd00200
    Location:485769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:14137
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. NM_011600.4NP_035730.2  transducin-like enhancer protein 4 isoform 2

    See identical proteins and their annotated locations for NP_035730.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter by one amino acid compared to isoform 1.
    Source sequence(s)
    AC122202, AC125315
    Consensus CDS
    CCDS50399.1
    UniProtKB/Swiss-Prot
    Q62441, Q9JKQ9
    UniProtKB/TrEMBL
    A0A6P5P0R6, Q3UY41
    Related
    ENSMUSP00000057527.8, ENSMUST00000052011.15
    Conserved Domains (3) summary
    cd00200
    Location:486770
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:490529
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:16138
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    14425436..14575547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526913.2XP_006526976.1  transducin-like enhancer protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006526976.1

    Conserved Domains (3) summary
    cd00200
    Location:461745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:465504
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8113
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  2. XM_030250862.2XP_030106722.1  transducin-like enhancer protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A6P5P327
    Conserved Domains (3) summary
    cd00200
    Location:484768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:14136
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  3. XM_030250864.2XP_030106724.1  transducin-like enhancer protein 4 isoform X4

    Conserved Domains (3) summary
    cd00200
    Location:459743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:463502
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:14107
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. XM_030250863.2XP_030106723.1  transducin-like enhancer protein 4 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:460744
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:464503
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:14101
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  5. XM_006526914.5XP_006526977.1  transducin-like enhancer protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A6P5NXB8
    Conserved Domains (3) summary
    cd00200
    Location:366650
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:370409
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:118
    TLE_N; Groucho/TLE N-terminal Q-rich domain