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TLE4 TLE family member 4, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7091, updated on 9-Dec-2018

Summary

Official Symbol
TLE4provided by HGNC
Official Full Name
TLE family member 4, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11840
See related
Ensembl:ENSG00000106829 MIM:605132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
Expression
Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more
Orthologs

Genomic context

See TLE4 in Genome Data Viewer
Location:
9q21.31
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (79571773..79726882)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (82186878..82341658)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1041 Neighboring gene uncharacterized LOC102723932 Neighboring gene VISTA enhancer hs1078 Neighboring gene VISTA enhancer hs1360 Neighboring gene ankyrin repeat domain-containing protein 36B pseudogene Neighboring gene long intergenic non-protein coding RNA 1507 Neighboring gene uncharacterized LOC105376101 Neighboring gene nuclear pore associated protein 1 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
NHGRI GWA Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
NHGRI GWA Catalog

Pathways from BioSystems

  • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
    Deactivation of the beta-catenin transactivating complex, organism-specific biosystemThe mechanisms involved in downregulation of TCF-dependent transcription are not yet very well understood. beta-catenin is known to recruit a number of transcriptional repressors, including Reptin, S...
  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
    Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
  • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
    Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
  • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
    NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
  • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
  • Repression of WNT target genes, organism-specific biosystem (from REACTOME)
    Repression of WNT target genes, organism-specific biosystemIn the absence of a WNT signal, many WNT target genes are repressed by Groucho/TLE. Groucho was initially identified in Drosophila, where it has been shown to interact with a variety of proteins to ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
biological_process ND
No biological Data available
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transducin-like enhancer protein 4
Names
B lymphocyte gene 1
enhancer of split groucho 4
groucho-related protein 4
transducin like enhancer of split 4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282748.1NP_001269677.1  transducin-like enhancer protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001269677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL353813, AL358975, BC059405
    Consensus CDS
    CCDS65069.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000365720.4, ENST00000376537.8
    Conserved Domains (4) summary
    COG2319
    Location:511803
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:518802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:522561
    7WD40; WD40 repeat [structural motif]
  2. NM_001282749.1NP_001269678.1  transducin-like enhancer protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001269678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK296342, AL353813, AL358975
    Consensus CDS
    CCDS65070.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000265284.6, ENST00000265284.10
    Conserved Domains (4) summary
    COG2319
    Location:454746
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:461745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:465504
    7WD40; WD40 repeat [structural motif]
  3. NM_001282753.1NP_001269682.1  transducin-like enhancer protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001269682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    AL353813, AL358975, BC045650
    Consensus CDS
    CCDS75851.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000365727.4, ENST00000376544.7
    Conserved Domains (3) summary
    cd00200
    Location:417701
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:421460
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. NM_001282760.1NP_001269689.1  transducin-like enhancer protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the coding region which results in the use of a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared the isoform 1.
    Source sequence(s)
    AL353813, AL358975, BC036369
    Conserved Domains (3) summary
    COG2319
    Location:364650
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:365649
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:369408
    7WD40; WD40 repeat [structural motif]
  5. NM_001351541.1NP_001338470.1  transducin-like enhancer protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, BC059405, BI462014, DR760461
    Conserved Domains (3) summary
    cd00200
    Location:499783
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:503542
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8151
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. NM_001351542.1NP_001338471.1  transducin-like enhancer protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, BC059405, BI462014, DB284195, DR760461
    Conserved Domains (3) summary
    cd00200
    Location:487771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:491530
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  7. NM_001351543.1NP_001338472.1  transducin-like enhancer protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, DB284195, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:485769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10137
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  8. NM_001351546.1NP_001338475.1  transducin-like enhancer protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:484768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10136
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  9. NM_001351547.1NP_001338476.1  transducin-like enhancer protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, HY012218
    Conserved Domains (3) summary
    cd00200
    Location:469753
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:473512
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10121
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  10. NM_001351550.1NP_001338479.1  transducin-like enhancer protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, AL358975, BC059405, DB284195
    Conserved Domains (3) summary
    cd00200
    Location:466750
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:470509
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  11. NM_001351552.1NP_001338481.1  transducin-like enhancer protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, AL358975, BC059405
    Conserved Domains (3) summary
    cd00200
    Location:465749
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:469508
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8117
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  12. NM_001351556.1NP_001338485.1  transducin-like enhancer protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:463747
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:467506
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10115
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  13. NM_001351558.1NP_001338487.1  transducin-like enhancer protein 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, AL358975, DB284195
    Conserved Domains (3) summary
    cd00200
    Location:462746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:466505
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8103
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  14. NM_001351560.1NP_001338489.1  transducin-like enhancer protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BI462045, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:460744
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:464503
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10101
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  15. NM_001351562.1NP_001338491.1  transducin-like enhancer protein 4 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, AL358975
    Conserved Domains (4) summary
    cd00200
    Location:410694
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:414453
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:239316
    Atrophin-1; Atrophin-1 family
  16. NM_001351563.1NP_001338492.1  transducin-like enhancer protein 4 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BI462045, BU428571, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:408692
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:412451
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10107
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  17. NM_001351564.1NP_001338493.1  transducin-like enhancer protein 4 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, AL358975
    Conserved Domains (3) summary
    cd00200
    Location:392676
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:396435
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  18. NM_007005.4NP_008936.2  transducin-like enhancer protein 4 isoform 3

    See identical proteins and their annotated locations for NP_008936.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AB033087, AL353813, AL358975
    Consensus CDS
    CCDS43837.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000365735.2, ENST00000376552.6
    Conserved Domains (4) summary
    COG2319
    Location:479771
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:486770
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:490529
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_104239.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057236, AL353813, AL358975

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    79571773..79726882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518952.1XP_011517254.1  transducin-like enhancer protein 4 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:578870
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:585869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:589628
    7WD40; WD40 repeat [structural motif]
  2. XM_006717264.1XP_006717327.1  transducin-like enhancer protein 4 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:553845
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:560844
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:564603
    7WD40; WD40 repeat [structural motif]
  3. XM_011518958.1XP_011517260.1  transducin-like enhancer protein 4 isoform X8

    Conserved Domains (4) summary
    COG2319
    Location:546838
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:553837
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:557596
    7WD40; WD40 repeat [structural motif]
  4. XM_006717268.1XP_006717331.1  transducin-like enhancer protein 4 isoform X13

    Conserved Domains (4) summary
    COG2319
    Location:521813
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:528812
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:532571
    7WD40; WD40 repeat [structural motif]
  5. XM_011518967.1XP_011517269.1  transducin-like enhancer protein 4 isoform X22

    Conserved Domains (4) summary
    COG2319
    Location:495787
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:502786
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:506545
    7WD40; WD40 repeat [structural motif]
  6. XM_017015074.1XP_016870563.1  transducin-like enhancer protein 4 isoform X25

  7. XM_011518969.1XP_011517271.1  transducin-like enhancer protein 4 isoform X24

    Conserved Domains (4) summary
    COG2319
    Location:477769
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:484768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
  8. XM_011518956.1XP_011517258.1  transducin-like enhancer protein 4 isoform X6

    Conserved Domains (4) summary
    COG2319
    Location:550842
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:557841
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:561600
    7WD40; WD40 repeat [structural motif]
  9. XM_011518957.1XP_011517259.1  transducin-like enhancer protein 4 isoform X7

    Conserved Domains (4) summary
    COG2319
    Location:549841
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:556840
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8151
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:560599
    7WD40; WD40 repeat [structural motif]
  10. XM_011518959.1XP_011517261.1  transducin-like enhancer protein 4 isoform X9

    Conserved Domains (4) summary
    COG2319
    Location:537829
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:544828
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:548587
    7WD40; WD40 repeat [structural motif]
  11. XM_011518965.1XP_011517267.1  transducin-like enhancer protein 4 isoform X20

    Conserved Domains (4) summary
    COG2319
    Location:505797
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:512796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:516555
    7WD40; WD40 repeat [structural motif]
  12. XM_017015081.1XP_016870570.1  transducin-like enhancer protein 4 isoform X27

  13. XM_011518960.1XP_011517262.1  transducin-like enhancer protein 4 isoform X10

    Conserved Domains (4) summary
    COG2319
    Location:536828
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:543827
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:547586
    7WD40; WD40 repeat [structural motif]
  14. XM_011518966.1XP_011517268.1  transducin-like enhancer protein 4 isoform X21

    Conserved Domains (4) summary
    COG2319
    Location:504796
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:511795
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:515554
    7WD40; WD40 repeat [structural motif]
  15. XM_017015083.1XP_016870572.1  transducin-like enhancer protein 4 isoform X28

  16. XM_011518963.1XP_011517265.1  transducin-like enhancer protein 4 isoform X16

    Conserved Domains (4) summary
    COG2319
    Location:512804
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:519803
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8103
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:523562
    7WD40; WD40 repeat [structural motif]
  17. XM_011518964.1XP_011517266.1  transducin-like enhancer protein 4 isoform X17

    Conserved Domains (4) summary
    COG2319
    Location:511803
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:518802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:522561
    7WD40; WD40 repeat [structural motif]
  18. XM_011518955.1XP_011517257.1  transducin-like enhancer protein 4 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:557849
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:564848
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8112
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:568607
    7WD40; WD40 repeat [structural motif]
  19. XM_011518961.1XP_011517263.1  transducin-like enhancer protein 4 isoform X14

    Conserved Domains (4) summary
    COG2319
    Location:516808
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:523807
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:527566
    7WD40; WD40 repeat [structural motif]
  20. XM_011518962.1XP_011517264.1  transducin-like enhancer protein 4 isoform X15

    Conserved Domains (4) summary
    COG2319
    Location:515807
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:522806
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8117
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:526565
    7WD40; WD40 repeat [structural motif]
  21. XM_011518968.1XP_011517270.1  transducin-like enhancer protein 4 isoform X23

    Conserved Domains (4) summary
    COG2319
    Location:491783
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:498782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:883
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:502541
    7WD40; WD40 repeat [structural motif]
  22. XM_011518954.1XP_011517256.1  transducin-like enhancer protein 4 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:563855
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:570854
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:574613
    7WD40; WD40 repeat [structural motif]
  23. XM_017015068.1XP_016870557.1  transducin-like enhancer protein 4 isoform X12

  24. XM_017015075.1XP_016870564.1  transducin-like enhancer protein 4 isoform X26

  25. XM_011518970.3XP_011517272.1  transducin-like enhancer protein 4 isoform X29

    Conserved Domains (2) summary
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:589628
    7WD40; WD40 repeat [structural motif]
  26. XM_017015070.1XP_016870559.1  transducin-like enhancer protein 4 isoform X19

  27. XM_017015067.1XP_016870556.1  transducin-like enhancer protein 4 isoform X11

  28. XM_011518953.2XP_011517255.1  transducin-like enhancer protein 4 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:576868
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:583867
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:13131
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:587626
    7WD40; WD40 repeat [structural motif]
  29. XM_017015069.2XP_016870558.1  transducin-like enhancer protein 4 isoform X18

  30. XM_011518972.3XP_011517274.1  transducin-like enhancer protein 4 isoform X30

    Conserved Domains (3) summary
    COG2319
    Location:221513
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:228512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232271
    7WD40; WD40 repeat [structural motif]
  31. XM_024447659.1XP_024303427.1  transducin-like enhancer protein 4 isoform X31

    Conserved Domains (2) summary
    cd00200
    Location:203487
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:207246
    7WD40; WD40 repeat [structural motif]
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