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TLE4 TLE family member 4, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7091, updated on 19-Sep-2024

Summary

Official Symbol
TLE4provided by HGNC
Official Full Name
TLE family member 4, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11840
See related
Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more
Orthologs
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Genomic context

See TLE4 in Genome Data Viewer
Location:
9q21.31
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (79571965..79726882)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (91730341..91885229)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (82186880..82341797)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19968 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82115206-82115783 Neighboring gene lncRNA regulator of Akt signaling associated with HCC and RCC Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:82187809-82188421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19974 Neighboring gene VISTA enhancer hs1078 Neighboring gene uncharacterized LOC124902329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82267149-82267908 Neighboring gene VISTA enhancer hs1360 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82346165-82346666 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82380198-82380813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:82449531-82450161 Neighboring gene long intergenic non-protein coding RNA 1507 Neighboring gene ankyrin repeat domain-containing protein 36B-like Neighboring gene uncharacterized LOC105376101 Neighboring gene nuclear pore associated protein 1 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
EBI GWAS Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transducin-like enhancer protein 4
Names
B lymphocyte gene 1
enhancer of split groucho 4
groucho-related protein 4
transducin like enhancer of split 4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282748.2NP_001269677.1  transducin-like enhancer protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001269677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL353813, AL358975, AL445252
    Consensus CDS
    CCDS65069.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000365720.4, ENST00000376537.8
    Conserved Domains (4) summary
    COG2319
    Location:511803
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:518802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:522561
    7WD40; WD40 repeat [structural motif]
  2. NM_001282749.2NP_001269678.1  transducin-like enhancer protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001269678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AL353813, AL358975
    Consensus CDS
    CCDS65070.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000265284.6, ENST00000265284.10
    Conserved Domains (4) summary
    COG2319
    Location:454746
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:461745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:465504
    7WD40; WD40 repeat [structural motif]
  3. NM_001282753.2NP_001269682.1  transducin-like enhancer protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001269682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    AL353813, AL358975, AL445252
    Consensus CDS
    CCDS75851.1
    UniProtKB/Swiss-Prot
    Q04727
    Related
    ENSP00000365727.4, ENST00000376544.7
    Conserved Domains (3) summary
    cd00200
    Location:417701
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:421460
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  4. NM_001282760.2NP_001269689.1  transducin-like enhancer protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the coding region which results in the use of a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared the isoform 1.
    Source sequence(s)
    AL353813, AL358975, AL445252
    Conserved Domains (3) summary
    COG2319
    Location:364650
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:365649
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:369408
    7WD40; WD40 repeat [structural motif]
  5. NM_001351541.2NP_001338470.1  transducin-like enhancer protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, AL445252
    Conserved Domains (3) summary
    cd00200
    Location:499783
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:503542
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8151
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  6. NM_001351542.2NP_001338471.1  transducin-like enhancer protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, AL445252
    Conserved Domains (3) summary
    cd00200
    Location:487771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:491530
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  7. NM_001351543.2NP_001338472.1  transducin-like enhancer protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, DB284195, HY012218, HY054961
    Consensus CDS
    CCDS94424.1
    UniProtKB/TrEMBL
    A0A994J7T6
    Related
    ENSP00000516378.1, ENST00000706431.1
    Conserved Domains (3) summary
    cd00200
    Location:485769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10137
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  8. NM_001351546.2NP_001338475.1  transducin-like enhancer protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:484768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10136
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  9. NM_001351547.2NP_001338476.1  transducin-like enhancer protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, HY012218
    Conserved Domains (3) summary
    cd00200
    Location:469753
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:473512
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10121
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  10. NM_001351550.2NP_001338479.1  transducin-like enhancer protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, AL445252
    Conserved Domains (3) summary
    cd00200
    Location:466750
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:470509
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  11. NM_001351552.2NP_001338481.1  transducin-like enhancer protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975, AL445252
    Conserved Domains (3) summary
    cd00200
    Location:465749
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:469508
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8117
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  12. NM_001351556.2NP_001338485.1  transducin-like enhancer protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BC059405, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:463747
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:467506
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10115
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  13. NM_001351558.2NP_001338487.1  transducin-like enhancer protein 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975
    Conserved Domains (3) summary
    cd00200
    Location:462746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:466505
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8103
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  14. NM_001351560.2NP_001338489.1  transducin-like enhancer protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BI462045, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:460744
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:464503
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10101
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  15. NM_001351562.2NP_001338491.1  transducin-like enhancer protein 4 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975
    Conserved Domains (4) summary
    cd00200
    Location:410694
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:414453
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl26464
    Location:239316
    Atrophin-1; Atrophin-1 family
  16. NM_001351563.2NP_001338492.1  transducin-like enhancer protein 4 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AK296342, AL353813, BI462045, BU428571, HY012218, HY054961
    Conserved Domains (3) summary
    cd00200
    Location:408692
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:412451
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10107
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  17. NM_001351564.2NP_001338493.1  transducin-like enhancer protein 4 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL353813, AL358975
    Conserved Domains (3) summary
    cd00200
    Location:392676
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:396435
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
  18. NM_007005.6NP_008936.2  transducin-like enhancer protein 4 isoform 3

    See identical proteins and their annotated locations for NP_008936.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AL353813, AL358975, AL445252
    Consensus CDS
    CCDS43837.1
    UniProtKB/Swiss-Prot
    F8W6T6, Q04727, Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9
    Related
    ENSP00000365735.2, ENST00000376552.8
    Conserved Domains (4) summary
    COG2319
    Location:479771
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:486770
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:490529
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_104239.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353813, AL358975, AL445252

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    79571965..79726882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518952.2XP_011517254.1  transducin-like enhancer protein 4 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:578870
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:585869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:589628
    7WD40; WD40 repeat [structural motif]
  2. XM_006717264.2XP_006717327.1  transducin-like enhancer protein 4 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:553845
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:560844
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:564603
    7WD40; WD40 repeat [structural motif]
  3. XM_011518958.2XP_011517260.1  transducin-like enhancer protein 4 isoform X8

    Conserved Domains (4) summary
    COG2319
    Location:546838
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:553837
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:557596
    7WD40; WD40 repeat [structural motif]
  4. XM_006717268.2XP_006717331.1  transducin-like enhancer protein 4 isoform X13

    Conserved Domains (4) summary
    COG2319
    Location:521813
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:528812
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:532571
    7WD40; WD40 repeat [structural motif]
  5. XM_011518967.2XP_011517269.1  transducin-like enhancer protein 4 isoform X20

    Conserved Domains (4) summary
    COG2319
    Location:495787
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:502786
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:506545
    7WD40; WD40 repeat [structural motif]
  6. XM_017015074.2XP_016870563.1  transducin-like enhancer protein 4 isoform X24

  7. XM_011518969.2XP_011517271.1  transducin-like enhancer protein 4 isoform X23

    Conserved Domains (4) summary
    COG2319
    Location:477769
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:484768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:488527
    7WD40; WD40 repeat [structural motif]
  8. XM_047423820.1XP_047279776.1  transducin-like enhancer protein 4 isoform X25

  9. XM_011518956.2XP_011517258.1  transducin-like enhancer protein 4 isoform X6

    Conserved Domains (4) summary
    COG2319
    Location:550842
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:557841
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:561600
    7WD40; WD40 repeat [structural motif]
  10. XM_047423819.1XP_047279775.1  transducin-like enhancer protein 4 isoform X21

  11. XM_011518957.2XP_011517259.1  transducin-like enhancer protein 4 isoform X7

    Conserved Domains (4) summary
    COG2319
    Location:549841
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:556840
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8151
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:560599
    7WD40; WD40 repeat [structural motif]
  12. XM_011518959.2XP_011517261.1  transducin-like enhancer protein 4 isoform X9

    Conserved Domains (4) summary
    COG2319
    Location:537829
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:544828
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:548587
    7WD40; WD40 repeat [structural motif]
  13. XM_011518965.2XP_011517267.1  transducin-like enhancer protein 4 isoform X18

    Conserved Domains (4) summary
    COG2319
    Location:505797
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:512796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8139
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:516555
    7WD40; WD40 repeat [structural motif]
  14. XM_047423823.1XP_047279779.1  transducin-like enhancer protein 4 isoform X28

  15. XM_011518960.2XP_011517262.1  transducin-like enhancer protein 4 isoform X10

    Conserved Domains (4) summary
    COG2319
    Location:536828
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:543827
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:547586
    7WD40; WD40 repeat [structural motif]
  16. XM_011518966.2XP_011517268.1  transducin-like enhancer protein 4 isoform X19

    Conserved Domains (4) summary
    COG2319
    Location:504796
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:511795
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8138
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:515554
    7WD40; WD40 repeat [structural motif]
  17. XM_017015083.2XP_016870572.1  transducin-like enhancer protein 4 isoform X29

  18. XM_011518963.2XP_011517265.1  transducin-like enhancer protein 4 isoform X16

    Conserved Domains (2) summary
    cd00200
    Location:519803
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:523562
    7WD40; WD40 repeat [structural motif]
  19. XM_011518964.2XP_011517266.1  transducin-like enhancer protein 4 isoform X17

    Conserved Domains (4) summary
    COG2319
    Location:511803
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:518802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8109
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:522561
    7WD40; WD40 repeat [structural motif]
  20. XM_011518955.2XP_011517257.1  transducin-like enhancer protein 4 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:557849
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:564848
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8112
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:568607
    7WD40; WD40 repeat [structural motif]
  21. XM_011518961.2XP_011517263.1  transducin-like enhancer protein 4 isoform X14

    Conserved Domains (4) summary
    COG2319
    Location:516808
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:523807
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:527566
    7WD40; WD40 repeat [structural motif]
  22. XM_011518962.2XP_011517264.1  transducin-like enhancer protein 4 isoform X15

    Conserved Domains (4) summary
    COG2319
    Location:515807
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:522806
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8117
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:526565
    7WD40; WD40 repeat [structural motif]
  23. XM_011518968.2XP_011517270.1  transducin-like enhancer protein 4 isoform X22

    Conserved Domains (4) summary
    COG2319
    Location:491783
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:498782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:883
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:502541
    7WD40; WD40 repeat [structural motif]
  24. XM_047423821.1XP_047279777.1  transducin-like enhancer protein 4 isoform X26

  25. XM_011518954.2XP_011517256.1  transducin-like enhancer protein 4 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:563855
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:570854
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:8118
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:574613
    7WD40; WD40 repeat [structural motif]
  26. XM_017015068.2XP_016870557.1  transducin-like enhancer protein 4 isoform X12

  27. XM_011518970.4XP_011517272.1  transducin-like enhancer protein 4 isoform X30

    Conserved Domains (2) summary
    pfam03920
    Location:8133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:589628
    7WD40; WD40 repeat [structural motif]
  28. XM_047423824.1XP_047279780.1  transducin-like enhancer protein 4 isoform X31

  29. XM_011518953.3XP_011517255.1  transducin-like enhancer protein 4 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:576868
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:583867
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:13131
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:587626
    7WD40; WD40 repeat [structural motif]
  30. XM_017015067.2XP_016870556.1  transducin-like enhancer protein 4 isoform X11

  31. XM_047423822.1XP_047279778.1  transducin-like enhancer protein 4 isoform X27

  32. XM_011518972.4XP_011517274.1  transducin-like enhancer protein 4 isoform X32

    Conserved Domains (2) summary
    cd00200
    Location:228512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232271
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    91730341..91885229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363677.1XP_054219652.1  transducin-like enhancer protein 4 isoform X1

  2. XM_054363681.1XP_054219656.1  transducin-like enhancer protein 4 isoform X5

  3. XM_054363684.1XP_054219659.1  transducin-like enhancer protein 4 isoform X8

  4. XM_054363689.1XP_054219664.1  transducin-like enhancer protein 4 isoform X13

  5. XM_054363696.1XP_054219671.1  transducin-like enhancer protein 4 isoform X20

  6. XM_054363701.1XP_054219676.1  transducin-like enhancer protein 4 isoform X24

  7. XM_054363699.1XP_054219674.1  transducin-like enhancer protein 4 isoform X23

  8. XM_054363702.1XP_054219677.1  transducin-like enhancer protein 4 isoform X25

  9. XM_054363682.1XP_054219657.1  transducin-like enhancer protein 4 isoform X6

  10. XM_054363697.1XP_054219672.1  transducin-like enhancer protein 4 isoform X21

  11. XM_054363683.1XP_054219658.1  transducin-like enhancer protein 4 isoform X7

  12. XM_054363685.1XP_054219660.1  transducin-like enhancer protein 4 isoform X9

  13. XM_054363694.1XP_054219669.1  transducin-like enhancer protein 4 isoform X18

  14. XM_054363705.1XP_054219680.1  transducin-like enhancer protein 4 isoform X28

  15. XM_054363686.1XP_054219661.1  transducin-like enhancer protein 4 isoform X10

  16. XM_054363695.1XP_054219670.1  transducin-like enhancer protein 4 isoform X19

  17. XM_054363706.1XP_054219681.1  transducin-like enhancer protein 4 isoform X29

  18. XM_054363692.1XP_054219667.1  transducin-like enhancer protein 4 isoform X16

  19. XM_054363693.1XP_054219668.1  transducin-like enhancer protein 4 isoform X17

  20. XM_054363680.1XP_054219655.1  transducin-like enhancer protein 4 isoform X4

  21. XM_054363700.1XP_054219675.1  transducin-like enhancer protein 4 isoform X33

  22. XM_054363690.1XP_054219665.1  transducin-like enhancer protein 4 isoform X14

  23. XM_054363691.1XP_054219666.1  transducin-like enhancer protein 4 isoform X15

  24. XM_054363698.1XP_054219673.1  transducin-like enhancer protein 4 isoform X22

  25. XM_054363703.1XP_054219678.1  transducin-like enhancer protein 4 isoform X26

  26. XM_054363679.1XP_054219654.1  transducin-like enhancer protein 4 isoform X3

  27. XM_054363688.1XP_054219663.1  transducin-like enhancer protein 4 isoform X12

  28. XM_054363707.1XP_054219682.1  transducin-like enhancer protein 4 isoform X30

  29. XM_054363708.1XP_054219683.1  transducin-like enhancer protein 4 isoform X31

  30. XM_054363678.1XP_054219653.1  transducin-like enhancer protein 4 isoform X2

  31. XM_054363687.1XP_054219662.1  transducin-like enhancer protein 4 isoform X11

  32. XM_054363704.1XP_054219679.1  transducin-like enhancer protein 4 isoform X27

  33. XM_054363709.1XP_054219684.1  transducin-like enhancer protein 4 isoform X32