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Tkt transketolase [ Mus musculus (house mouse) ]

Gene ID: 21881, updated on 8-Feb-2024

Summary

Official Symbol
Tktprovided by MGI
Official Full Name
transketolaseprovided by MGI
Primary source
MGI:MGI:105992
See related
Ensembl:ENSMUSG00000021957 AllianceGenome:MGI:105992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p68
Summary
This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]
Expression
Broad expression in mammary gland adult (RPKM 585.4), adrenal adult (RPKM 535.9) and 24 other tissues See more
Orthologs
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Genomic context

See Tkt in Genome Data Viewer
Location:
14 B; 14 18.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30271088..30296681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30549131..30574724)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit Neighboring gene RIKEN cDNA 4831407H17 gene Neighboring gene STARR-seq mESC enhancer starr_36297 Neighboring gene predicted gene, 35566 Neighboring gene decapping mRNA 1A Neighboring gene STARR-positive B cell enhancer ABC_E7300 Neighboring gene STARR-seq mESC enhancer starr_36303 Neighboring gene STARR-positive B cell enhancer ABC_E11567 Neighboring gene STARR-positive B cell enhancer ABC_E2422 Neighboring gene microRNA 3076 Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta Neighboring gene predicted gene, 53839

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiamine pyrophosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transketolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transketolase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transketolase
Names
TK
NP_033414.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009388.6NP_033414.1  transketolase

    See identical proteins and their annotated locations for NP_033414.1

    Status: REVIEWED

    Source sequence(s)
    AC154646, AI837706, AK030446, AK166763, BY276711
    Consensus CDS
    CCDS26894.1
    UniProtKB/Swiss-Prot
    P40142, Q3U7Y1, Q3UK62, Q545A1, Q9ESA0
    UniProtKB/TrEMBL
    A0A286YE28
    Related
    ENSMUSP00000022529.7, ENSMUST00000022529.8
    Conserved Domains (4) summary
    cd07033
    Location:319474
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:8620
    PRK05899; transketolase; Reviewed
    cd02012
    Location:20271
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:492612
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30271088..30296681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)