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Tkt transketolase [ Mus musculus (house mouse) ]

Gene ID: 21881, updated on 3-Nov-2024

Summary

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Official Symbol
Tktprovided by MGI
Official Full Name
transketolaseprovided by MGI
Primary source
MGI:MGI:105992
See related
Ensembl:ENSMUSG00000021957 AllianceGenome:MGI:105992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p68
Summary
This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]
Expression
Broad expression in mammary gland adult (RPKM 585.4), adrenal adult (RPKM 535.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tkt in Genome Data Viewer
Location:
14 B; 14 18.79 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30271088..30296681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30549131..30574724)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit Neighboring gene RIKEN cDNA 4831407H17 gene Neighboring gene STARR-seq mESC enhancer starr_36297 Neighboring gene predicted gene, 35566 Neighboring gene decapping mRNA 1A Neighboring gene STARR-positive B cell enhancer ABC_E7300 Neighboring gene STARR-seq mESC enhancer starr_36303 Neighboring gene STARR-positive B cell enhancer ABC_E11567 Neighboring gene STARR-positive B cell enhancer ABC_E2422 Neighboring gene microRNA 3076 Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta Neighboring gene predicted gene, 53839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. Schimmer BP, et al. J Biol Chem, 1996 Mar 1. PMID 8617775
  2. Transketolase and protein oxidation of senescence accelerated mouse. Nakamura J, et al. Biofactors, 2000. PMID 10705983
  3. Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency. Zhao Y, et al. J Neurochem, 2009 Oct. PMID 19686241
  4. The mouse transketolase (TKT) gene: cloning, characterization, and functional promoter analysis. Salamon C, et al. Genomics, 1998 Mar 1. PMID 9521875
  5. Heterogeneous expression of transketolase in ocular tissues. Guo J, et al. Curr Eye Res, 1997 May. PMID 9154385

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
    Title: HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
  2. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics.
    Title: Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics.
  3. Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis.
    Title: Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis.
  4. TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis.
    Title: TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis.
  5. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
    Title: Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
  6. Zinc finger protein 746 overexpression suppresses TKT transcription via IRS-like motif in the TKT promoter.
    Title: Identification of transketolase as a target of PARIS in substantia nigra.
  7. decreased TK activity leads to pentose-phosphate pathway dysfunction and contributes to impaired hippocampal neurogenesis induced by thiamine deficiency
    Title: Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine pyrophosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transketolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glyceraldehyde-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xylulose 5-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transketolase
Names
TK
NP_033414.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009388.6 → NP_033414.1  transketolase

    See identical proteins and their annotated locations for NP_033414.1

    Status: REVIEWED

    Source sequence(s)
    AC154646, AI837706, AK030446, AK166763, BY276711
    Consensus CDS
    CCDS26894.1
    UniProtKB/Swiss-Prot
    P40142, Q3U7Y1, Q3UK62, Q545A1, Q9ESA0
    UniProtKB/TrEMBL
    A0A286YE28
    Related
    ENSMUSP00000022529.7, ENSMUST00000022529.8
    Conserved Domains (4) summary
    cd07033
    Location:319 → 474
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:8 → 620
    PRK05899; transketolase; Reviewed
    cd02012
    Location:20 → 271
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:492 → 612
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30271088..30296681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40142.1 GenPept UniProtKB/Swiss-Prot:P40142

Gene LinkOut

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