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TKT transketolase [ Homo sapiens (human) ]

Gene ID: 7086, updated on 5-Aug-2018

Summary

Official Symbol
TKTprovided by HGNC
Official Full Name
transketolaseprovided by HGNC
Primary source
HGNC:HGNC:11834
See related
Ensembl:ENSG00000163931 MIM:606781; Vega:OTTHUMG00000158192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TK; TKT1; SDDHD; HEL107; HEL-S-48
Summary
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Expression
Broad expression in bone marrow (RPKM 210.7), fat (RPKM 83.0) and 22 other tissues See more
Orthologs

Genomic context

See TKT in Genome Data Viewer
Location:
3p21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (53224707..53256114, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53258723..53290130, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RFT1 homolog Neighboring gene protein kinase C delta Neighboring gene uncharacterized LOC107986087 Neighboring gene decapping mRNA 1A Neighboring gene small nucleolar RNA, C/D box 38C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of transketolase (TKT) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human transketolase (TKT) at amino acid residues178-179 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
transketolase activity EXP
Inferred from Experiment
more info
PubMed 
transketolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
glyceraldehyde-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
pentose-phosphate shunt, non-oxidative branch NAS
Non-traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
xylulose biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
transketolase
Names
epididymis luminal protein 107
epididymis secretory protein Li 48
NP_001055.1
NP_001128527.1
NP_001244957.1
XP_011532356.1
XP_011532357.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027815.1 RefSeqGene

    Range
    5001..36408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001064.3NP_001055.1  transketolase isoform 1

    See identical proteins and their annotated locations for NP_001055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC009970, BC024026, CA421169, DB503248, L12711
    Consensus CDS
    CCDS2871.1
    UniProtKB/Swiss-Prot
    P29401
    UniProtKB/TrEMBL
    V9HWD9
    Related
    ENSP00000417773.1, OTTHUMP00000212664, ENST00000462138.5, OTTHUMT00000350356
    Conserved Domains (1) summary
    PRK05899
    Location:8620
    PRK05899; transketolase; Reviewed
  2. NM_001135055.2NP_001128527.1  transketolase isoform 1

    See identical proteins and their annotated locations for NP_001128527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC097015, BE504944, BX647248, DB503248
    Consensus CDS
    CCDS2871.1
    UniProtKB/Swiss-Prot
    P29401
    UniProtKB/TrEMBL
    V9HWD9
    Related
    ENSP00000405455.2, OTTHUMP00000212668, ENST00000423525.6, OTTHUMT00000350362
    Conserved Domains (1) summary
    PRK05899
    Location:8620
    PRK05899; transketolase; Reviewed
  3. NM_001258028.1NP_001244957.1  transketolase isoform 2

    See identical proteins and their annotated locations for NP_001244957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AK293438, BC008615, CA421169, DB503248
    Consensus CDS
    CCDS58834.1
    UniProtKB/Swiss-Prot
    P29401
    Related
    ENSP00000391481.1, OTTHUMP00000212667, ENST00000423516.5, OTTHUMT00000350359
    Conserved Domains (4) summary
    cd07033
    Location:327482
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:8628
    PRK05899; transketolase; Reviewed
    cd02012
    Location:20279
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:500620
    Transketolase_C; Transketolase, C-terminal domain

RNA

  1. NR_047580.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK301231, BC008615, CA421169, DB503248
    Related
    ENST00000450814.6, OTTHUMT00000350358

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    53224707..53256114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534054.1XP_011532356.1  transketolase isoform X1

    See identical proteins and their annotated locations for XP_011532356.1

    UniProtKB/Swiss-Prot
    P29401
    Conserved Domains (4) summary
    cd07033
    Location:327482
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:8628
    PRK05899; transketolase; Reviewed
    cd02012
    Location:20279
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:500620
    Transketolase_C; Transketolase, C-terminal domain
  2. XM_011534055.2XP_011532357.1  transketolase isoform X2

    See identical proteins and their annotated locations for XP_011532357.1

    UniProtKB/TrEMBL
    A0A0B4J1R6
    Related
    ENSP00000296289.7, ENST00000296289.10
    Conserved Domains (1) summary
    cl27366
    Location:1454
    TktA; Transketolase [Carbohydrate transport and metabolism]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135056.1: Suppressed sequence

    Description
    NM_001135056.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with non-consensus splice sites.
  2. NR_047579.1: Suppressed sequence

    Description
    NR_047579.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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