U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tjp2 tight junction protein 2 [ Mus musculus (house mouse) ]

Gene ID: 21873, updated on 8-Jan-2023

Summary

Official Symbol
Tjp2provided by MGI
Official Full Name
tight junction protein 2provided by MGI
Primary source
MGI:MGI:1341872
See related
Ensembl:ENSMUSG00000024812 AllianceGenome:MGI:1341872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZO-2
Summary
Predicted to enable several functions, including cell adhesion molecule binding activity; protein C-terminus binding activity; and protein tyrosine kinase binding activity. Acts upstream of or within TNFSF11-mediated signaling pathway and negative regulation of osteoclast development. Located in nucleus; plasma membrane; and tight junction. Is expressed in several structures, including early embryo; genitourinary system; inner ear; neural ectoderm; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 24.4), small intestine adult (RPKM 19.3) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tjp2 in Genome Data Viewer
Location:
19; 19 B
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24071860..24202492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24094496..24225128, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41823 Neighboring gene predicted gene, 41824 Neighboring gene frataxin Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tight junction protein ZO-2
Names
Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
zona occludens protein 2
zonula occludens protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198985.2NP_001185914.1  tight junction protein ZO-2 isoform 1

    See identical proteins and their annotated locations for NP_001185914.1

    Status: VALIDATED

    Source sequence(s)
    AC149224, AK028494, BM224980, BP767126, BQ176958, CB724174, CF736959, CN527767, CN529621
    Consensus CDS
    CCDS37939.2
    UniProtKB/TrEMBL
    A0A3B2WCN9
    Related
    ENSMUSP00000156605.2, ENSMUST00000233027.2
    Conserved Domains (5) summary
    cd12027
    Location:607669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:705884
    GuKc; Guanylate kinase homologues
    smart00228
    Location:311388
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08648
    Location:219283
    DUF1777; Protein of unknown function (DUF1777)
  2. NM_001360391.1NP_001347320.1  tight junction protein ZO-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107685, AC149224, BQ176958
    Conserved Domains (4) summary
    cd12027
    Location:611673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:709888
    GuKc; Guanylate kinase homologues
    smart00228
    Location:315392
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001360392.1NP_001347321.1  tight junction protein ZO-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107685, AC149224, BQ176958, BY073294
    Conserved Domains (4) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001376368.1NP_001363297.1  tight junction protein ZO-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107685, AC149224
    UniProtKB/Swiss-Prot
    Q8K210
    Related
    ENSMUSP00000156896.2, ENSMUST00000232956.2
    Conserved Domains (4) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. NM_011597.5NP_035727.2  tight junction protein ZO-2 isoform 2

    See identical proteins and their annotated locations for NP_035727.2

    Status: VALIDATED

    Source sequence(s)
    AC149224, AK028494, BM224980, BP767126, BQ176958, BY032291, CB724174, CF736959, CN527767, CN529621
    Consensus CDS
    CCDS89365.1
    UniProtKB/Swiss-Prot
    Q8K210, Q9Z0U1
    Related
    ENSMUSP00000097154.5, ENSMUST00000099558.5
    Conserved Domains (4) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    24071860..24202492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318136.2XP_017173625.1  tight junction protein ZO-2 isoform X6

    Conserved Domains (4) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_036161512.1XP_036017405.1  tight junction protein ZO-2 isoform X3

    UniProtKB/Swiss-Prot
    Q8K210
    Related
    ENSMUSP00000156728.3, ENSMUST00000233658.3
    Conserved Domains (4) summary
    cd12027
    Location:584646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:682861
    GuKc; Guanylate kinase homologues
    smart00228
    Location:288365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:994
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_030250861.2XP_030106721.1  tight junction protein ZO-2 isoform X5

    Conserved Domains (4) summary
    cd12027
    Location:607669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:705884
    GuKc; Guanylate kinase homologues
    smart00228
    Location:311388
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_006526904.5XP_006526967.1  tight junction protein ZO-2 isoform X1

    Conserved Domains (4) summary
    cd12027
    Location:625687
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:723902
    GuKc; Guanylate kinase homologues
    smart00228
    Location:329406
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:50135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_006526909.3XP_006526972.1  tight junction protein ZO-2 isoform X4

    Conserved Domains (4) summary
    cd12027
    Location:611673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:709888
    GuKc; Guanylate kinase homologues
    smart00228
    Location:315392
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006526907.3XP_006526970.1  tight junction protein ZO-2 isoform X2

    Conserved Domains (4) summary
    cd12027
    Location:625687
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:723902
    GuKc; Guanylate kinase homologues
    smart00228
    Location:329406
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:50135
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...