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Tjp1 tight junction protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21872, updated on 8-Feb-2024

Summary

Official Symbol
Tjp1provided by MGI
Official Full Name
tight junction protein 1provided by MGI
Primary source
MGI:MGI:98759
See related
Ensembl:ENSMUSG00000030516 AllianceGenome:MGI:98759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZO1
Summary
Enables connexin binding activity and protein domain specific binding activity. Involved in negative regulation of stress fiber assembly; positive regulation of sprouting angiogenesis; and protein localization to cell-cell junction. Acts upstream of or within blastocyst formation and sensory perception of sound. Located in several cellular components, including apicolateral plasma membrane; bicellular tight junction; and intercellular canaliculus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 23.6), bladder adult (RPKM 20.6) and 26 other tissues See more
Orthologs
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Genomic context

See Tjp1 in Genome Data Viewer
Location:
7 C; 7 35.02 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (64945913..65177629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (65296165..65527850, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19055 Neighboring gene RIKEN cDNA 1810049I09 gene Neighboring gene predicted gene, 17918 Neighboring gene STARR-seq mESC enhancer starr_19056 Neighboring gene STARR-seq mESC enhancer starr_19058 Neighboring gene STARR-seq mESC enhancer starr_19059 Neighboring gene STARR-seq mESC enhancer starr_19061 Neighboring gene cDNA sequence BC046251 Neighboring gene STARR-positive B cell enhancer ABC_E1341 Neighboring gene threonyl-tRNA synthetase 3 Neighboring gene predicted gene, 51484

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables connexin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
involved_in adherens junction maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood-brain barrier permeability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to adherens junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
tight junction protein ZO-1
Names
zona occludens protein 1
zonula occludens protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163574.2NP_001157046.1  tight junction protein ZO-1 isoform 2

    See identical proteins and their annotated locations for NP_001157046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the middle region but has an additional in-frame segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122222, AC131741
    Consensus CDS
    CCDS52266.1
    UniProtKB/TrEMBL
    B9EHJ3
    Related
    ENSMUSP00000032729.7, ENSMUST00000032729.8
    Conserved Domains (7) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11421501
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:15531650
    ZU5; ZU5 domain
  2. NM_001417366.1NP_001404295.1  tight junction protein ZO-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122222, AC131741
  3. NM_001417367.1NP_001404296.1  tight junction protein ZO-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122222, AC131741
  4. NM_001417368.1NP_001404297.1  tight junction protein ZO-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122222, AC131741
  5. NM_001417369.1NP_001404298.1  tight junction protein ZO-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131741
    UniProtKB/TrEMBL
    Q91YW2
  6. NM_001417370.1NP_001404299.1  tight junction protein ZO-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC131741
    UniProtKB/TrEMBL
    Q91YW2
  7. NM_001417371.1NP_001404300.1  tight junction protein ZO-1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC131741
    UniProtKB/TrEMBL
    Q91YW2
  8. NM_001417372.1NP_001404301.1  tight junction protein ZO-1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC131741
    UniProtKB/TrEMBL
    Q91YW2
  9. NM_001417373.1NP_001404302.1  tight junction protein ZO-1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC122222, AC122809
  10. NM_001417374.1NP_001404303.1  tight junction protein ZO-1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC122222
  11. NM_009386.3NP_033412.2  tight junction protein ZO-1 isoform 1

    See identical proteins and their annotated locations for NP_033412.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122222, AC131741
    Consensus CDS
    CCDS21338.1
    UniProtKB/Swiss-Prot
    E9QK00, P39447
    Related
    ENSMUSP00000099652.4, ENSMUST00000102592.10
    Conserved Domains (6) summary
    smart00218
    Location:16291735
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    64945913..65177629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540780.5XP_006540843.1  tight junction protein ZO-1 isoform X3

    Conserved Domains (7) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061688
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:17251824
    ZU5; ZU5 domain
  2. XM_006540778.5XP_006540841.1  tight junction protein ZO-1 isoform X1

    Conserved Domains (8) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061705
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:12271403
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:17421841
    ZU5; ZU5 domain
  3. XM_006540785.5XP_006540848.1  tight junction protein ZO-1 isoform X9

    Conserved Domains (8) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:12351594
    PHA03247; large tegument protein UL36; Provisional
    PRK03427
    Location:11631274
    PRK03427; cell division protein ZipA; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16451744
    ZU5; ZU5 domain
  4. XM_006540783.5XP_006540846.1  tight junction protein ZO-1 isoform X7

    Conserved Domains (8) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:11681655
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:11471323
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16621761
    ZU5; ZU5 domain
  5. XM_030242356.2XP_030098216.1  tight junction protein ZO-1 isoform X10

    Conserved Domains (8) summary
    cd12026
    Location:505569
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:603782
    GuKc; Guanylate kinase homologues
    smart00228
    Location:171251
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:9011600
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:11221298
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:1095
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:413489
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16371736
    ZU5; ZU5 domain
  6. XM_036152893.1XP_036008786.1  tight junction protein ZO-1 isoform X14

    Conserved Domains (8) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10751562
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:10541230
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:15691668
    ZU5; ZU5 domain
  7. XM_006540784.5XP_006540847.1  tight junction protein ZO-1 isoform X8

    Conserved Domains (8) summary
    cd12026
    Location:517581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:9131612
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:11341310
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:22107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16491748
    ZU5; ZU5 domain
  8. XM_006540786.5XP_006540849.1  tight junction protein ZO-1 isoform X13

    Conserved Domains (8) summary
    smart00218
    Location:16421748
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:12351594
    PHA03247; large tegument protein UL36; Provisional
    PRK03427
    Location:11631274
    PRK03427; cell division protein ZipA; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
  9. XM_036152892.1XP_036008785.1  tight junction protein ZO-1 isoform X12

    Conserved Domains (8) summary
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:12351594
    PHA03247; large tegument protein UL36; Provisional
    PRK03427
    Location:11631274
    PRK03427; cell division protein ZipA; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:16451734
    ZU5; ZU5 domain
  10. XM_006540782.5XP_006540845.1  tight junction protein ZO-1 isoform X6

    Conserved Domains (7) summary
    smart00218
    Location:17221828
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061688
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
  11. XM_011250843.4XP_011249145.1  tight junction protein ZO-1 isoform X5

    Conserved Domains (7) summary
    smart00218
    Location:17221835
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061688
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
  12. XM_006540781.5XP_006540844.1  tight junction protein ZO-1 isoform X4

    Conserved Domains (8) summary
    smart00218
    Location:17391845
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061705
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:12271403
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)
  13. XM_006540779.5XP_006540842.1  tight junction protein ZO-1 isoform X2

    Conserved Domains (8) summary
    smart00218
    Location:17391852
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03247
    Location:10061705
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:12271403
    PRK10263; DNA translocase FtsK; Provisional
    cd00992
    Location:115200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518594
    PDZ; PDZ domain (Also known as DHR or GLGF)