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BPTF bromodomain PHD finger transcription factor [ Homo sapiens (human) ]

Gene ID: 2186, updated on 7-Oct-2018

Summary

Official Symbol
BPTFprovided by HGNC
Official Full Name
bromodomain PHD finger transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3581
See related
Ensembl:ENSG00000171634 MIM:601819; Vega:OTTHUMG00000132254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAC1; FALZ; NEDDFL; NURF301
Summary
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See BPTF in Genome Data Viewer
Location:
17q24.2
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (67825517..67984378)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65821644..65980494)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 67 Neighboring gene ribosomal protein L17 pseudogene 41 Neighboring gene RNA, 7SL, cytoplasmic 622, pseudogene Neighboring gene chromosome 17 open reading frame 58 Neighboring gene transfer RNA-Arg (CCG) 2-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIES
MedGen: C4540327 OMIM: 617755 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
NHGRI GWA Catalog
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
NHGRI GWA Catalog

Pathways from BioSystems

  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NURF complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleosome-remodeling factor subunit BPTF
Names
bromodomain and PHD domain transcription factor
bromodomain and PHD finger-containing transcription factor
fetal Alz-50 clone 1 protein
fetal Alz-50 reactive clone 1
fetal Alzheimer antigen
nucleosome remodeling factor, large subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052828.1 RefSeqGene

    Range
    5148..163862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004459.6NP_004450.3  nucleosome-remodeling factor subunit BPTF isoform 2

    See identical proteins and their annotated locations for NP_004450.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two additional in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB032251, AC134407, AK022570, AK025776, AL833375, AY282495, BC037422
    UniProtKB/Swiss-Prot
    Q12830
    Related
    ENSP00000388405.3, OTTHUMP00000163084, ENST00000424123.7, OTTHUMT00000255333
    Conserved Domains (6) summary
    cd05509
    Location:27882888
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:21632583
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27262772
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  2. NM_182641.3NP_872579.2  nucleosome-remodeling factor subunit BPTF isoform 1

    See identical proteins and their annotated locations for NP_872579.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB032251, AC134407, AK022570, AK025776, AY282495, BC037422, CV809604
    Consensus CDS
    CCDS11673.1
    UniProtKB/Swiss-Prot
    Q12830
    Related
    ENSP00000307208.6, OTTHUMP00000163085, ENST00000306378.10, OTTHUMT00000255334
    Conserved Domains (6) summary
    cd05509
    Location:28052905
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20372418
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27432789
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    67825517..67984378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257152.3XP_005257209.1  nucleosome-remodeling factor subunit BPTF isoform X4

    Conserved Domains (7) summary
    cd05509
    Location:30433143
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27422972
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29813027
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  2. XM_005257150.3XP_005257207.1  nucleosome-remodeling factor subunit BPTF isoform X1

    Conserved Domains (7) summary
    cd05509
    Location:30433143
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27422972
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29813027
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  3. XM_017024353.2XP_016879842.1  nucleosome-remodeling factor subunit BPTF isoform X12

  4. XM_005257154.3XP_005257211.1  nucleosome-remodeling factor subunit BPTF isoform X6

    Related
    ENSP00000315454.4, ENST00000321892.8
    Conserved Domains (6) summary
    cd05509
    Location:29853085
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:22172598
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29232969
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  5. XM_024450647.1XP_024306415.1  nucleosome-remodeling factor subunit BPTF isoform X16

    Conserved Domains (9) summary
    cd05509
    Location:29003000
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:240299
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28382884
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam09606
    Location:21752520
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15612
    Location:344381
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:456524
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02572
    Location:14101669
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cl26267
    Location:25992829
    ING; Inhibitor of growth proteins N-terminal histone-binding
  6. XM_005257159.2XP_005257216.1  nucleosome-remodeling factor subunit BPTF isoform X15

    Conserved Domains (7) summary
    cd05509
    Location:29003000
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25992829
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22172637
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28382884
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  7. XM_005257161.3XP_005257218.1  nucleosome-remodeling factor subunit BPTF isoform X19

    Conserved Domains (6) summary
    cd05509
    Location:28422942
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:22172637
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27802826
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  8. XM_005257153.3XP_005257210.1  nucleosome-remodeling factor subunit BPTF isoform X5

    Related
    ENSP00000496182.1, ENST00000644067.1
    Conserved Domains (7) summary
    cd05509
    Location:29893089
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26882918
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21632544
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29272973
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  9. XM_005257160.2XP_005257217.1  nucleosome-remodeling factor subunit BPTF isoform X18

    Related
    ENSP00000343837.4, ENST00000342579.8
    Conserved Domains (7) summary
    cd05509
    Location:28462946
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25452775
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21632583
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27842830
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  10. XM_005257151.3XP_005257208.1  nucleosome-remodeling factor subunit BPTF isoform X3

    Conserved Domains (7) summary
    cd05509
    Location:30423142
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27412971
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22162597
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29803026
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  11. XM_011524520.2XP_011522822.1  nucleosome-remodeling factor subunit BPTF isoform X2

    Conserved Domains (7) summary
    cd05509
    Location:30423142
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:27412971
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:22162597
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29803026
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  12. XM_005257155.3XP_005257212.1  nucleosome-remodeling factor subunit BPTF isoform X7

    Conserved Domains (7) summary
    cd05509
    Location:29803080
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26792909
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21542535
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29182964
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  13. XM_005257157.3XP_005257214.1  nucleosome-remodeling factor subunit BPTF isoform X9

    Conserved Domains (7) summary
    cd05509
    Location:29793079
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26782908
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21532534
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29172963
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  14. XM_005257156.3XP_005257213.1  nucleosome-remodeling factor subunit BPTF isoform X8

    Conserved Domains (7) summary
    cd05509
    Location:29803080
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26792909
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21542535
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29182964
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  15. XM_024450646.1XP_024306414.1  nucleosome-remodeling factor subunit BPTF isoform X11

    Conserved Domains (9) summary
    cd05509
    Location:29793079
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:240299
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29172963
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam09606
    Location:21212496
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15612
    Location:344381
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:456524
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl02572
    Location:13461605
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cl26267
    Location:26782908
    ING; Inhibitor of growth proteins N-terminal histone-binding
  16. XM_011524521.2XP_011522823.1  nucleosome-remodeling factor subunit BPTF isoform X10

    Conserved Domains (7) summary
    cd05509
    Location:29793079
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26782908
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:21532534
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29172963
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  17. XM_005257158.3XP_005257215.1  nucleosome-remodeling factor subunit BPTF isoform X13

    Conserved Domains (7) summary
    cd05509
    Location:29173017
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26162846
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20912472
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28552901
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  18. XM_011524522.2XP_011522824.1  nucleosome-remodeling factor subunit BPTF isoform X14

    Conserved Domains (7) summary
    cd05509
    Location:29163016
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:26152845
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20902471
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28542900
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  19. XM_011524523.2XP_011522825.1  nucleosome-remodeling factor subunit BPTF isoform X17

    Conserved Domains (7) summary
    cd05509
    Location:28622962
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:25612791
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:20362417
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28002846
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  20. XM_011524525.2XP_011522827.1  nucleosome-remodeling factor subunit BPTF isoform X22

    Conserved Domains (6) summary
    cd05509
    Location:28042904
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20362417
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27422788
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  21. XM_011524526.2XP_011522828.1  nucleosome-remodeling factor subunit BPTF isoform X23

    Conserved Domains (6) summary
    cd05509
    Location:26612761
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam09606
    Location:20362456
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15559
    Location:392434
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:25992645
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam02791
    Location:241297
    DDT; DDT domain
    pfam15612
    Location:339388
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
  22. XM_017024354.2XP_016879843.1  nucleosome-remodeling factor subunit BPTF isoform X20

  23. XM_011524524.3XP_011522826.1  nucleosome-remodeling factor subunit BPTF isoform X21

    Conserved Domains (4) summary
    cd05509
    Location:20732173
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5034
    Location:17722002
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    pfam09606
    Location:12471628
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15560
    Location:20112057
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

RNA

  1. XR_001752449.1 RNA Sequence

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