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Timp1 tissue inhibitor of metalloproteinase 1 [ Mus musculus (house mouse) ]

Gene ID: 21857, updated on 5-Mar-2024

Summary

Official Symbol
Timp1provided by MGI
Official Full Name
tissue inhibitor of metalloproteinase 1provided by MGI
Primary source
MGI:MGI:98752
See related
Ensembl:ENSMUSG00000001131 AllianceGenome:MGI:98752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPA; Clgi; Timp; TIMP-1; TPA-S1
Summary
Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 113.3), adrenal adult (RPKM 13.6) and 5 other tissues See more
Orthologs
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Genomic context

See Timp1 in Genome Data Viewer
Location:
X A1.3; X 16.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20736524..20740972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20870166..20874737)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Araf proto-oncogene, serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1532 Neighboring gene ribonuclease UK114 pseudogene Neighboring gene microRNA 5617 Neighboring gene synapsin I Neighboring gene STARR-seq mESC enhancer starr_46887 Neighboring gene STARR-seq mESC enhancer starr_46888 Neighboring gene complement factor properdin Neighboring gene ELK1, member of ETS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC7143

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metalloproteinase inhibitor 1
Names
TPA-induced protein
collagenase inhibitor 16C8 fibroblast
erythroid-potentiating activity
tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044384.2NP_001037849.1  metalloproteinase inhibitor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001037849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL671885
    Consensus CDS
    CCDS30046.1
    UniProtKB/Swiss-Prot
    P12032, P20064, Q61720
    Related
    ENSMUSP00000009530.5, ENSMUST00000009530.5
    Conserved Domains (1) summary
    smart00206
    Location:25199
    NTR; Tissue inhibitor of metalloproteinase family
  2. NM_001294280.3NP_001281209.1  metalloproteinase inhibitor 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
    Source sequence(s)
    AL671885
    Conserved Domains (1) summary
    cl02512
    Location:1131
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
  3. NM_001426018.1NP_001412947.1  metalloproteinase inhibitor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL671885
  4. NM_001426019.1NP_001412948.1  metalloproteinase inhibitor 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL671885
  5. NM_001426020.1NP_001412949.1  metalloproteinase inhibitor 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL671885
  6. NM_011593.3NP_035723.2  metalloproteinase inhibitor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_035723.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL671885
    Consensus CDS
    CCDS30046.1
    UniProtKB/Swiss-Prot
    P12032, P20064, Q61720
    Related
    ENSMUSP00000110999.4, ENSMUST00000115342.10
    Conserved Domains (1) summary
    smart00206
    Location:25199
    NTR; Tissue inhibitor of metalloproteinase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20736524..20740972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)