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TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 7076, updated on 27-Dec-2020

Summary

Official Symbol
TIMP1provided by HGNC
Official Full Name
TIMP metallopeptidase inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:11820
See related
Ensembl:ENSG00000102265 MIM:305370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPA; EPO; HCI; CLGI; TIMP; TIMP-1
Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 344.6), gall bladder (RPKM 211.2) and 15 other tissues See more
Orthologs
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Genomic context

See TIMP1 in Genome Data Viewer
Location:
Xp11.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47582408..47586789)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47441690..47446190)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4668 Neighboring gene A-Raf proto-oncogene, serine/threonine kinase Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element Neighboring gene synapsin I Neighboring gene microRNA 4769 Neighboring gene complement factor properdin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat downregulates both basal and bFGF-induced secretion of TIMP-1 and TIMP-2, an effect involved in the Tat and bFGF induced increase in MMP-2 secretion PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of TIMP metallopeptidase inhibitor 1 (TIMP1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell activation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
connective tissue replacement involved in inflammatory response wound healing IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
metalloproteinase inhibitor 1
Names
collagenase inhibitor
epididymis secretory sperm binding protein
erythroid potentiating activity
fibroblast collagenase inhibitor
tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012533.1 RefSeqGene

    Range
    5146..9499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003254.3NP_003245.1  metalloproteinase inhibitor 1 precursor

    See identical proteins and their annotated locations for NP_003245.1

    Status: REVIEWED

    Source sequence(s)
    BC000866, BC007097
    Consensus CDS
    CCDS14281.1
    UniProtKB/Swiss-Prot
    P01033
    UniProtKB/TrEMBL
    Q6FGX5
    Related
    ENSP00000218388.4, ENST00000218388.9
    Conserved Domains (1) summary
    smart00206
    Location:24199
    NTR; Tissue inhibitor of metalloproteinase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47582408..47586789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029766.2XP_016885255.1  metalloproteinase inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    B4DJK3
    Conserved Domains (1) summary
    cl02512
    Location:104147
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
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