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Tgtp1 T cell specific GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 21822, updated on 11-Apr-2024

Summary

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Official Symbol
Tgtp1provided by MGI
Official Full Name
T cell specific GTPase 1provided by MGI
Primary source
MGI:MGI:98734
See related
Ensembl:ENSMUSG00000078922 AllianceGenome:MGI:98734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtp2; Mg21; Tgtp; Irgb6; Tgtp2; Ifggb6
Summary
Enables GTPase activity. Involved in response to virus. Acts upstream of or within several processes, including cellular response to interferon-beta; response to interferon-alpha; and response to interferon-gamma. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; integumental system; nervous system; and nose. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 8.2), liver E18 (RPKM 7.6) and 17 other tissues See more
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Genomic context

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See Tgtp1 in Genome Data Viewer
Location:
11 B1.2; 11 28.98 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48876156..48883073, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48985329..48992246, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12185 Neighboring gene RIKEN cDNA 9930111J21 gene 1 Neighboring gene protease (prosome, macropain) activator subunit 2B Neighboring gene STARR-positive B cell enhancer mm9_chr11:48793591-48793892 Neighboring gene predicted gene, 42074 Neighboring gene STARR-seq mESC enhancer starr_29366 Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29368 Neighboring gene RIKEN cDNA 9930111J21 gene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:48863673-48863974

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases. Carlow DA, et al. J Immunol, 1998 Sep 1. PMID 9725230
  2. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Lee Y, et al. Life Sci Alliance, 2020 Jan. PMID 31852733, Free PMC Article
  3. Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif. Carlow DA, et al. J Immunol, 1995 Feb 15. PMID 7836757
  4. Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Khaminets A, et al. Cell Microbiol, 2010 Jul. PMID 20109161, Free PMC Article
  5. Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. Lafuse WP, et al. J Leukoc Biol, 1995 Mar. PMID 7884320

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
    Title: Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to interferon-alpha IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
T-cell-specific guanine nucleotide triphosphate-binding protein 1
Names
Interferon-gamma-inducible GTPase Ifggb6 protein
T-cell specific GTPase
T-cell-specific guanine nucleotide triphosphate-binding protein 2
interferon-gamma-inducible GTPase Ifggb5
NP_035709.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011579.3 → NP_035709.3  T-cell-specific guanine nucleotide triphosphate-binding protein 1

    See identical proteins and their annotated locations for NP_035709.3

    Status: VALIDATED

    Source sequence(s)
    AA177827, AK163978, AL627237, BY238768
    Consensus CDS
    CCDS24593.1
    UniProtKB/Swiss-Prot
    Q3T9E4, Q60711, Q62293, Q8BN19
    UniProtKB/TrEMBL
    A0A1G5SLN0, U5NJF8
    Related
    ENSMUSP00000069914.4, ENSMUST00000068063.4
    Conserved Domains (2) summary
    cd04104
    Location:56 → 252
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:22 → 395
    IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48876156..48883073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62293.1 GenPept UniProtKB/Swiss-Prot:Q62293

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