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Tgfb2 transforming growth factor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 21808, updated on 24-Jan-2023

Summary

Official Symbol
Tgfb2provided by MGI
Official Full Name
transforming growth factor, beta 2provided by MGI
Primary source
MGI:MGI:98726
See related
Ensembl:ENSMUSG00000039239 AllianceGenome:MGI:98726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgfb-2; Tgf-beta2
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Expression
Broad expression in limb E14.5 (RPKM 8.0), CNS E11.5 (RPKM 3.4) and 17 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Tgfb2 in Genome Data Viewer
Location:
1 H5; 1 89.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (186354984..186441504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (186622787..186709697, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730004F24 gene Neighboring gene predicted gene, 35546 Neighboring gene predicted gene, 26169 Neighboring gene predicted gene, 35655 Neighboring gene RIKEN cDNA A430105J06 gene Neighboring gene ribosomal RNA processing 15 homolog Neighboring gene RIKEN cDNA 1700023G09 gene Neighboring gene predicted gene, 39732

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type III transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type III transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of activation-induced cell death of T cells IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ascending aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum primum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac right ventricle morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic neurocranium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in eye development ISO
Inferred from Sequence Orthology
more info
 
involved_in face morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membranous septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in neural retina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in pericyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of activation-induced cell death of T cells IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix disassembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of timing of catagen ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of timing of catagen ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in substantia propria of cornea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
part_of transforming growth factor beta complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transforming growth factor beta-2 proprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329107.1NP_001316036.1  transforming growth factor beta-2 proprotein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC154879, AK029306, AK141552, AK159690, AK163286
    Consensus CDS
    CCDS83659.1
    UniProtKB/TrEMBL
    A0A0A6YXU9, A0A8C6MP73, Q3TWH5, Q8CDZ9
    Related
    ENSMUSP00000142149.2, ENSMUST00000195201.2
    Conserved Domains (2) summary
    pfam00019
    Location:344441
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:21256
    TGFb_propeptide; TGF-beta propeptide
  2. NM_009367.4NP_033393.2  transforming growth factor beta-2 proprotein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC154879, AK029306, AK159690, AK163286
    Consensus CDS
    CCDS15601.1
    UniProtKB/Swiss-Prot
    P27090, Q91VP5
    UniProtKB/TrEMBL
    A0A8C6MP75, Q3TWH5, Q8CDZ9
    Related
    ENSMUSP00000043849.9, ENSMUST00000045288.14
    Conserved Domains (2) summary
    pfam00019
    Location:316413
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:21228
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    186354984..186441504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252968.2XP_030108828.1  transforming growth factor beta-2 proprotein isoform X2

    Conserved Domains (1) summary
    pfam00688
    Location:21228
    TGFb_propeptide; TGF-beta propeptide
  2. XM_006497136.5XP_006497199.1  transforming growth factor beta-2 proprotein isoform X1

    Conserved Domains (1) summary
    pfam00688
    Location:21256
    TGFb_propeptide; TGF-beta propeptide