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Tgfa transforming growth factor alpha [ Mus musculus (house mouse) ]

Gene ID: 21802, updated on 8-Jul-2021

Summary

Official Symbol
Tgfaprovided by MGI
Official Full Name
transforming growth factor alphaprovided by MGI
Primary source
MGI:MGI:98724
See related
Ensembl:ENSMUSG00000029999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wa1; wa-1
Summary
This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in ovary adult (RPKM 6.7), CNS E18 (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

See Tgfa in Genome Data Viewer
Location:
6 D1; 6 37.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86172020..86252726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86195038..86275744)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (86145245..86225443)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adducin 2 (beta) Neighboring gene predicted gene, 19596 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S28 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protransforming growth factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031199.5NP_112476.1  protransforming growth factor alpha preproprotein

    See identical proteins and their annotated locations for NP_112476.1

    Status: REVIEWED

    Source sequence(s)
    AC159549
    Consensus CDS
    CCDS51832.1
    UniProtKB/Swiss-Prot
    P48030
    UniProtKB/TrEMBL
    Q545E4
    Related
    ENSMUSP00000032066.10, ENSMUST00000032066.13
    Conserved Domains (2) summary
    PHA02887
    Location:4382
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:46120
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86172020..86252726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255312.1XP_030111172.1  protransforming growth factor alpha isoform X1

    Conserved Domains (2) summary
    PHA02887
    Location:4382
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:46120
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
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