Format

Send to

Choose Destination
Dev Biol. 2015 Oct 15;406(2):147-57. doi: 10.1016/j.ydbio.2015.09.003. Epub 2015 Sep 10.

Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.

Author information

1
Department of Ophthalmology, University of Cincinnati, OH 45267, United States; Eye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China.
2
Department of Ophthalmology, University of Cincinnati, OH 45267, United States.
3
Eye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China.
4
Eye Institute of Xiamen University, Xiamen, Fujian 361102, People's Republic of China. Electronic address: zuguoliu@xmu.edu.cn.
5
Department of Ophthalmology, University of Cincinnati, OH 45267, United States. Electronic address: kaoww@uc.edu.

Abstract

Transforming growth factor alpha (TGFα) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGFα did not change proliferation and differentiation of meibocytes, but promoted proliferation and inhibited differentiation of the tarsal plate tenocytes. These results suggest that proper formation of the tendon and tarsal plate in the mouse eyelid is required for normal morphogenesis of the meibomian gland.

KEYWORDS:

ECM; Eyelid development; Eyelid tendon; Meibomian gland morphogenesis; TGFα; Tarsal plate

PMID:
26363126
PMCID:
PMC4996271
DOI:
10.1016/j.ydbio.2015.09.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center