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Tfdp1 transcription factor Dp 1 [ Mus musculus (house mouse) ]

Gene ID: 21781, updated on 12-Aug-2018

Summary

Official Symbol
Tfdp1provided by MGI
Official Full Name
transcription factor Dp 1provided by MGI
Primary source
MGI:MGI:101934
See related
Ensembl:ENSMUSG00000038482 Vega:OTTMUSG00000060903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dp1; Drtf1
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.8), liver E14 (RPKM 51.3) and 28 other tissues See more
Orthologs

Genomic context

See Tfdp1 in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (13338726..13378448)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13339674..13377702)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
anoikis IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor Dp-1
Names
DRTF1-polypeptide 1
E2F dimerization partner 1
cell cycle regulatory transcription factor DP1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291765.1NP_001278694.1  transcription factor Dp-1 isoform a

    See identical proteins and their annotated locations for NP_001278694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC130818, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Related
    ENSMUSP00000147881.1, OTTMUSP00000077325, ENSMUST00000209885.1, OTTMUST00000148852
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200339
    DP; Transcription factor DP
  2. NM_001291766.1NP_001278695.1  transcription factor Dp-1 isoform b

    See identical proteins and their annotated locations for NP_001278695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AC130818, AK013180, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q3V3X3, Q9CYZ7, Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  3. NM_001291768.1NP_001278697.1  transcription factor Dp-1 isoform b

    See identical proteins and their annotated locations for NP_001278697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, resulting in the use of a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AK019997, AK030820, BY089512, CO041118
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q3V3X3, Q9CYZ7, Q9D297
    Related
    ENSMUSP00000147662.1, OTTMUSP00000077326, ENSMUST00000209396.1, OTTMUST00000148853
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  4. NM_001358991.1NP_001345920.1  transcription factor Dp-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AC130818, CO041118
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  5. NM_009361.3NP_033387.1  transcription factor Dp-1 isoform a

    See identical proteins and their annotated locations for NP_033387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC130818, AK019997, AK030820, CO041118
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200339
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    13338726..13378448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312657.1XP_017168146.1  transcription factor Dp-1 isoform X1

  2. XM_011242048.1XP_011240350.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_011240350.1

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  3. XM_017312658.1XP_017168147.1  transcription factor Dp-1 isoform X1

  4. XM_006508754.1XP_006508817.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  5. XM_006508755.1XP_006508818.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_006508818.1

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
  6. XM_017312659.1XP_017168148.1  transcription factor Dp-1 isoform X1

  7. XM_006508751.3XP_006508814.1  transcription factor Dp-1 isoform X2

    See identical proteins and their annotated locations for XP_006508814.1

    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200339
    DP; Transcription factor DP
  8. XM_006508758.3XP_006508821.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_006508821.1

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:173
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80218
    DP; Transcription factor DP
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