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TFDP1 transcription factor Dp-1 [ Homo sapiens (human) ]

Gene ID: 7027, updated on 23-Sep-2022

Summary

Official Symbol
TFDP1provided by HGNC
Official Full Name
transcription factor Dp-1provided by HGNC
Primary source
HGNC:HGNC:11749
See related
Ensembl:ENSG00000198176 MIM:189902; AllianceGenome:HGNC:11749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP1; DILC; Dp-1; DRTF1
Summary
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues See more
Orthologs
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Genomic context

See TFDP1 in Genome Data Viewer
Location:
13q34
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113584688..113641473)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112843768..112900540)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114239003..114295788)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene uncharacterized LOC124903219 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anoikis IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IC
Inferred by Curator
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fat cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IC
Inferred by Curator
more info
 
involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IC
Inferred by Curator
more info
 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of Rb-E2F complex IC
Inferred by Curator
more info
 
part_of Rb-E2F complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor Dp-1
Names
DRTF1-polypeptide 1
E2F dimerization partner 1
E2F-related transcription factor
down-regulated in liver cancer stem cells

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029909.1 RefSeqGene

    Range
    5066..61786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007111.5NP_009042.1  transcription factor Dp-1

    See identical proteins and their annotated locations for NP_009042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL442125, BC011685
    Consensus CDS
    CCDS9538.1
    UniProtKB/Swiss-Prot
    Q14186, Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
    Related
    ENSP00000364519.4, ENST00000375370.10
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP

RNA

  1. NR_026580.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK297114, AL442125, CD623680

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113584688..113641473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020717.2XP_016876206.1  transcription factor Dp-1 isoform X1

  2. XM_005268327.2XP_005268384.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_005268384.1

    UniProtKB/Swiss-Prot
    Q14186, Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  3. XM_017020718.2XP_016876207.1  transcription factor Dp-1 isoform X4

    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  4. XM_017020719.3XP_016876208.1  transcription factor Dp-1 isoform X6

    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200335
    DP; Transcription factor DP
  5. XM_047430562.1XP_047286518.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
  6. XM_047430566.1XP_047286522.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
  7. XM_047430569.1XP_047286525.1  transcription factor Dp-1 isoform X4

  8. XM_047430554.1XP_047286510.1  transcription factor Dp-1 isoform X1

  9. XM_047430561.1XP_047286517.1  transcription factor Dp-1 isoform X2

  10. XM_047430570.1XP_047286526.1  transcription factor Dp-1 isoform X4

  11. XM_047430575.1XP_047286531.1  transcription factor Dp-1 isoform X6

  12. XM_047430564.1XP_047286520.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
  13. XM_047430568.1XP_047286524.1  transcription factor Dp-1 isoform X4

  14. XM_047430558.1XP_047286514.1  transcription factor Dp-1 isoform X1

  15. XM_047430573.1XP_047286529.1  transcription factor Dp-1 isoform X6

  16. XM_047430560.1XP_047286516.1  transcription factor Dp-1 isoform X1

  17. XM_047430574.1XP_047286530.1  transcription factor Dp-1 isoform X6

  18. XM_005268328.3XP_005268385.1  transcription factor Dp-1 isoform X4

    See identical proteins and their annotated locations for XP_005268385.1

    Conserved Domains (3) summary
    cd14458
    Location:198244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200338
    DP; Transcription factor DP
  19. XM_047430557.1XP_047286513.1  transcription factor Dp-1 isoform X1

  20. XM_047430559.1XP_047286515.1  transcription factor Dp-1 isoform X1

  21. XM_047430563.1XP_047286519.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    Q8IZL5
    UniProtKB/TrEMBL
    A0A024RDY4
  22. XM_047430567.1XP_047286523.1  transcription factor Dp-1 isoform X4

  23. XM_047430572.1XP_047286528.1  transcription factor Dp-1 isoform X6

  24. XM_047430571.1XP_047286527.1  transcription factor Dp-1 isoform X5

  25. XM_047430576.1XP_047286532.1  transcription factor Dp-1 isoform X7

  26. XM_047430577.1XP_047286533.1  transcription factor Dp-1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112843768..112900540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)