U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mis18bp1 MIS18 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 217653, updated on 11-Apr-2024

Summary

Official Symbol
Mis18bp1provided by MGI
Official Full Name
MIS18 binding protein 1provided by MGI
Primary source
MGI:MGI:2145099
See related
Ensembl:ENSMUSG00000047534 AllianceGenome:MGI:2145099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Knl2; mKIAA1903; 6720403H11
Summary
Predicted to enable DNA binding activity. Predicted to act upstream of or within cell division. Predicted to be located in chromosome, centromeric region and nucleus. Is expressed in midbrain ventricular layer; nephrogenic zone; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MIS18BP1 (MIS18 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 12.0), liver E14 (RPKM 9.4) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mis18bp1 in Genome Data Viewer
Location:
12 C1; 12 27.21 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65179508..65219363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (65132734..65172581, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene STARR-positive B cell enhancer ABC_E5331 Neighboring gene STARR-positive B cell enhancer ABC_E4026 Neighboring gene FK506 binding protein 3 Neighboring gene Fanconi anemia, complementation group M Neighboring gene STARR-seq mESC enhancer starr_32318 Neighboring gene STARR-seq mESC enhancer starr_32320 Neighboring gene predicted gene, 31063 Neighboring gene STARR-seq mESC enhancer starr_32321 Neighboring gene WD repeat domain 20, retrogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1903

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CENP-A recruiting complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mis18-binding protein 1
Names
kinetochore-associated protein KNL-2 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419213.1NP_001406142.1  mis18-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159885
  2. NM_172578.3NP_766166.2  mis18-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_766166.2

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159885
    Consensus CDS
    CCDS25942.1
    UniProtKB/Swiss-Prot
    Q571G6, Q80WQ8, Q8BPR7, Q8CBB5, Q8CG92
    UniProtKB/TrEMBL
    Q8BS57
    Related
    ENSMUSP00000052109.9, ENSMUST00000052201.9
    Conserved Domains (3) summary
    smart00717
    Location:744788
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:745788
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam09133
    Location:338425
    SANTA; SANTA (SANT Associated)

RNA

  1. NR_185035.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159885
  2. NR_185036.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159621, AC159885

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    65179508..65219363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157309.1XP_036013202.1  mis18-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8K3D2
    Conserved Domains (1) summary
    cd00167
    Location:143186
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...