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Inmt indolethylamine N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 21743, updated on 1-Mar-2024

Summary

Official Symbol
Inmtprovided by MGI
Official Full Name
indolethylamine N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:102963
See related
Ensembl:ENSMUSG00000003477 AllianceGenome:MGI:102963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Temt
Summary
Enables thioether S-methyltransferase activity. Predicted to be involved in amine metabolic process and methylation. Predicted to act upstream of or within response to toxic substance. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and skeleton. Orthologous to human INMT (indolethylamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 556.8), liver adult (RPKM 128.3) and 1 other tissue See more
Orthologs
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Genomic context

See Inmt in Genome Data Viewer
Location:
6 B3; 6 27.38 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55147612..55151975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55170627..55174990, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene STARR-seq mESC enhancer starr_15973 Neighboring gene predicted gene, 34358 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene predicted gene, 38819

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables amine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables dimethyl selenide methyltransferase activity TAS
Traceable Author Statement
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables thioether S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioether S-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
indolethylamine N-methyltransferase
Names
amine N-methyltransferase
aromatic alkylamine N-methyltransferase
arylamine N-methyltransferase
indolamine N-methyltransferase
nicotine N-methyltransferase
thioether S-methyltransferase
NP_033375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009349.3NP_033375.1  indolethylamine N-methyltransferase

    See identical proteins and their annotated locations for NP_033375.1

    Status: PROVISIONAL

    Source sequence(s)
    AC079243
    Consensus CDS
    CCDS20163.1
    UniProtKB/Swiss-Prot
    P40936, Q9CZ50
    Related
    ENSMUSP00000003569.6, ENSMUST00000003569.6
    Conserved Domains (1) summary
    pfam01234
    Location:1260
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55147612..55151975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)