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INMT indolethylamine N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 11185, updated on 6-Oct-2024

Summary

Official Symbol
INMTprovided by HGNC
Official Full Name
indolethylamine N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:6069
See related
Ensembl:ENSG00000241644 MIM:604854; AllianceGenome:HGNC:6069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEMT
Summary
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]
Expression
Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues See more
Orthologs
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Genomic context

See INMT in Genome Data Viewer
Location:
7p14.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30752135..30757602)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30889798..30895267)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30791751..30797218)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC124901608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30727952-30728462 Neighboring gene uncharacterized LOC105375220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30747055-30747555 Neighboring gene uncharacterized LOC105375219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30766987-30767488 Neighboring gene INMT-MINDY4 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18072 Neighboring gene Sharpr-MPRA regulatory region 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18073 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:30823626-30824126 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25819 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30893171-30894073 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30901315-30901474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30923659-30924560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30941843-30942646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30942647-30943449 Neighboring gene oxysterol binding protein like 9 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30946833-30947332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30948457-30948956 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30961348-30961528 Neighboring gene aquaporin 1 (Colton blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough INMT-MINDY4

Readthrough gene: INMT-MINDY4, Included gene: MINDY4

Clone Names

  • MGC125940, MGC125941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioether S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
indolethylamine N-methyltransferase
Names
amine N-methyltransferase
aromatic alkylamine N-methyltransferase
arylamine N-methyltransferase
indolamine N-methyltransferase
nicotine N-methyltransferase
thioether S-methyltransferase
NP_001186148.1
NP_006765.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047126.1 RefSeqGene

    Range
    5001..10468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199219.2NP_001186148.1  indolethylamine N-methyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC006022, AK313832, BC033813, DA920005
    Consensus CDS
    CCDS56479.1
    UniProtKB/TrEMBL
    A0A090N7V3, Q3MIB5
    Related
    ENSP00000386961.1, ENST00000409539.1
    Conserved Domains (1) summary
    pfam01234
    Location:4258
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
  2. NM_006774.5NP_006765.4  indolethylamine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006765.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006022, AF128846, BC033813
    Consensus CDS
    CCDS5430.1
    UniProtKB/Swiss-Prot
    B8ZZ69, O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0
    UniProtKB/TrEMBL
    A0A090N7V3, Q3MIB5
    Related
    ENSP00000013222.5, ENST00000013222.5
    Conserved Domains (1) summary
    pfam01234
    Location:4259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    30752135..30757602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    30889798..30895267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)