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INMT indolethylamine N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 11185, updated on 22-Mar-2020

Summary

Official Symbol
INMTprovided by HGNC
Official Full Name
indolethylamine N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:6069
See related
Ensembl:ENSG00000241644 MIM:604854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEMT
Summary
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]
Expression
Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues See more
Orthologs

Genomic context

See INMT in Genome Data Viewer
Location:
7p14.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (30752135..30757602)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30791689..30806152)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC105375220 Neighboring gene uncharacterized LOC105375219 Neighboring gene INMT-MINDY4 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 4 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene oxysterol binding protein like 9 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough INMT-MINDY4

Readthrough gene: INMT-MINDY4, Included gene: MINDY4

Homology

Clone Names

  • MGC125940, MGC125941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
amine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioether S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
methylation IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
indolethylamine N-methyltransferase
Names
amine N-methyltransferase
aromatic alkylamine N-methyltransferase
arylamine N-methyltransferase
indolamine N-methyltransferase
nicotine N-methyltransferase
thioether S-methyltransferase
NP_001186148.1
NP_006765.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047126.1 RefSeqGene

    Range
    5001..10468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199219.2NP_001186148.1  indolethylamine N-methyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC006022, AK313832, BC033813, DA920005
    Consensus CDS
    CCDS56479.1
    UniProtKB/Swiss-Prot
    O95050
    Related
    ENSP00000386961.1, ENST00000409539.1
    Conserved Domains (1) summary
    pfam01234
    Location:4258
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
  2. NM_006774.5NP_006765.4  indolethylamine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006765.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006022, AF128846, BC033813
    Consensus CDS
    CCDS5430.1
    UniProtKB/Swiss-Prot
    O95050
    Related
    ENSP00000013222.5, ENST00000013222.5
    Conserved Domains (1) summary
    pfam01234
    Location:4259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    30752135..30757602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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