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FABP7 fatty acid binding protein 7 [ Homo sapiens (human) ]

Gene ID: 2173, updated on 7-Dec-2018

Summary

Official Symbol
FABP7provided by HGNC
Official Full Name
fatty acid binding protein 7provided by HGNC
Primary source
HGNC:HGNC:3562
See related
Ensembl:ENSG00000164434 MIM:602965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRG; BLBP; FABPB; B-FABP
Summary
The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
Expression
Biased expression in brain (RPKM 8.9) and skin (RPKM 0.4) See more
Orthologs

Genomic context

See FABP7 in Genome Data Viewer
Location:
6q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (122749201..122784077)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (123100646..123105219)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267966 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene Neighboring gene sphingomyelin phosphodiesterase acid like 3A Neighboring gene ATP synthase membrane subunit g pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp547J2313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation in forebrain IEA
Inferred from Electronic Annotation
more info
 
epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neurogenesis IEA
Inferred from Electronic Annotation
more info
 
prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
triglyceride catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fatty acid-binding protein, brain
Names
brain lipid-binding protein
brain-type fatty acid-binding protein
hypothetical protein DKFZp547J2313
mammary-derived growth inhibitor-related

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050619.1 RefSeqGene

    Range
    35275..39877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001319039.1NP_001305968.1  fatty acid-binding protein, brain isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL512688, AL645811, BI860090
    Consensus CDS
    CCDS83121.1
    UniProtKB/Swiss-Prot
    O15540
    Related
    ENSP00000348931.4, ENST00000356535.4
    Conserved Domains (1) summary
    pfam00061
    Location:8117
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001319041.1NP_001305970.1  fatty acid-binding protein, brain isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) retains two alternate segments compared to variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB208815, AL645811, BI860090, BU736791, BX461253
    UniProtKB/TrEMBL
    Q59HE4
    Conserved Domains (1) summary
    pfam00061
    Location:883
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  3. NM_001319042.1NP_001305971.1  fatty acid-binding protein, brain isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. The 5' end of this transcript contains long terminal repeat (LTR) sequence and initiates from an LTR promoter. (PMID: 25114248)
    Source sequence(s)
    AW156936, BU736791, KM111186
    UniProtKB/TrEMBL
    A0A077H155
    Conserved Domains (1) summary
    pfam00061
    Location:21128
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  4. NM_001446.5NP_001437.1  fatty acid-binding protein, brain isoform 1

    See identical proteins and their annotated locations for NP_001437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AW156936, BC012299
    Consensus CDS
    CCDS5127.1
    UniProtKB/Swiss-Prot
    O15540
    Related
    ENSP00000357429.3, ENST00000368444.7
    Conserved Domains (1) summary
    pfam00061
    Location:8132
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    122749201..122784077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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