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Nr1d1 nuclear receptor subfamily 1, group D, member 1 [ Mus musculus (house mouse) ]

Gene ID: 217166, updated on 11-Nov-2019

Summary

Official Symbol
Nr1d1provided by MGI
Official Full Name
nuclear receptor subfamily 1, group D, member 1provided by MGI
Primary source
MGI:MGI:2444210
See related
Ensembl:ENSMUSG00000020889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R75201; A530070C09Rik
Summary
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]
Expression
Broad expression in adrenal adult (RPKM 224.5), lung adult (RPKM 118.7) and 21 other tissues See more
Orthologs

Genomic context

See Nr1d1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98767932..98775377, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98629249..98636556, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD124 Neighboring gene mediator complex subunit 24 Neighboring gene predicted gene, 31252 Neighboring gene thyroid hormone receptor alpha Neighboring gene predicted gene, 31862 Neighboring gene male specific lethal 1 Neighboring gene predicted gene 12359

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
heme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bile acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian sleep/wake cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to leptin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to leptin IDA
Inferred from Direct Assay
more info
PubMed 
response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 1 group D member 1
Names
EAR-1
REV-ERBalpha
Rev-ErbA-alpha protein
V-erbA-related protein 1
nuclear receptor protein
orphan nuclear receptor
rev-erb alpha
rev-erbA alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145434.4NP_663409.2  nuclear receptor subfamily 1 group D member 1

    See identical proteins and their annotated locations for NP_663409.2

    Status: VALIDATED

    Source sequence(s)
    AK155597, CD776678
    Consensus CDS
    CCDS25363.1
    UniProtKB/Swiss-Prot
    Q3UV55
    Related
    ENSMUSP00000069505.6, ENSMUST00000064941.6
    Conserved Domains (2) summary
    cd07166
    Location:128216
    NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
    cl11397
    Location:419612
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    98767932..98775377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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