1HLZ


Conserved Protein Domain Family
NR_DBD_REV_ERB

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cd07166: NR_DBD_REV_ERB 
Click on image for an interactive view with Cn3D
DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
DNA-binding domain of REV-ERB receptor- like is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which coordinates a single zinc atom. This domain interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. REV-ERB receptors are transcriptional regulators belonging to the nuclear receptor superfamily. They regulate a number of physiological functions including the circadian rhythm, lipid metabolism, and cellular differentiation. REV-ERB receptors bind as a monomer to a (A/G)GGTCA half-site with a 5' AT-rich extension or as a homodimer to a direct repeat 2 element (AGGTCA sequence with a 2-bp spacer), indicating functional diversity. When bound to the DNA, they recruit corepressors (NcoR/histone deacetylase 3) to the promoter, resulting in repression of the target genes. The porphyrin heme has been demonstrated to function as a ligand for REV-ERB receptor. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, REV-ERB receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143540
View PSSM: cd07166
Aligned: 10 rows
Threshold Bit Score: 144.232
Threshold Setting Gi: 17942647
Created: 2-Feb-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1HLZ_A; zinc binding site of human Orphan Nuclear Receptor Rev- Erb, contacts determined at 4A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the coordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  #             #  #                #     #         #  #                  
1HLZ_A          5 GMVLLCKVCGDVASGFHYGVLACEGCKGFFRRSIQQnIQYKRCLKNenCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFG 84
gi 148226871  110 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNetCSIVRINRNRCQQCRFRKCLSVGMSRDAVRFG 189
gi 51556245   123 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNetCTIMRINRNRCQQCRFKKCLSVGMSRDAVRFG 202
gi 45383934    73 GMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQnIQYKKCLKNnnCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFG 152
gi 6015044     42 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 121
gi 215492869   34 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 113
gi 189182188  240 GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQkIQYRPCTKNqqCSILRINRNRCQYCRLKKCIAVGMSRDAVRFG 319
gi 72010643     8 GYAVLCRVCGDKASGFHYGVHACEGCKGFFRRSIQHnVKYRVCSKGdeCLIMRINRNRCQYCRLKKCLAVGMSKDAVRLG 87
gi 219413546   13 GMMILCKVCGDKASGFHYGVHACEGCKGFFRRSIQQkIQYKQCTKNekCSIMRVNRNRCQHCRLKKCLAVGMSRDAVRFG 92
gi 118344280   42 LLDMPCKVCGDKSSGVHYGVYSCEGCKGFFRRTIHQkIKYRSCILDrtCSITKINRNRCQTCRFMKCLYVGMSKDAVKYG 121

                  ....*....
Feature 1                  
1HLZ_A         85 RIPKREKQR 93
gi 148226871  190 RIPKREKQR 198
gi 51556245   203 RIPKREKQR 211
gi 45383934   153 RIPKREKQR 161
gi 6015044    122 RVPKREKAR 130
gi 215492869  114 RVPKREKAK 122
gi 189182188  320 RVPKREKAR 328
gi 72010643    88 RCPKKCKPQ 96
gi 219413546   93 RVPKREKAR 101
gi 118344280  122 RIPKKQKAR 130

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