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Scrn2 secernin 2 [ Mus musculus (house mouse) ]

Gene ID: 217140, updated on 5-Mar-2024

Summary

Official Symbol
Scrn2provided by MGI
Official Full Name
secernin 2provided by MGI
Primary source
MGI:MGI:1343092
See related
Ensembl:ENSMUSG00000020877 AllianceGenome:MGI:1343092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SES2; D11Moh48
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Is expressed in submandibular gland primordium; testis; and thymus primordium. Orthologous to human SCRN2 (secernin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 36.7), duodenum adult (RPKM 23.4) and 25 other tissues See more
Orthologs
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Genomic context

See Scrn2 in Genome Data Viewer
Location:
11 D; 11 60.62 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96920717..96924786)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97029893..97033960)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene trans-acting transcription factor 6 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene predicted gene 11532 Neighboring gene leucine rich repeat containing 46 Neighboring gene predicted gene 11533 Neighboring gene STARR-positive B cell enhancer ABC_E909 Neighboring gene mitochondrial ribosomal protein L10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • MGC29406

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146027.2NP_666139.1  secernin-2

    See identical proteins and their annotated locations for NP_666139.1

    Status: VALIDATED

    Source sequence(s)
    AK075869, BF464943, CN691874
    Consensus CDS
    CCDS25310.1
    UniProtKB/Swiss-Prot
    Q8VCA8
    Related
    ENSMUSP00000021249.5, ENSMUST00000021249.11
    Conserved Domains (1) summary
    cl00467
    Location:11401
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96920717..96924786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314480.3XP_017169969.1  secernin-2 isoform X1

    Conserved Domains (1) summary
    cl00467
    Location:29419
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RNA

  1. XR_004936926.1 RNA Sequence

  2. XR_003949396.1 RNA Sequence