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SCRN2 secernin 2 [ Homo sapiens (human) ]

Gene ID: 90507, updated on 23-Nov-2021

Summary

Official Symbol
SCRN2provided by HGNC
Official Full Name
secernin 2provided by HGNC
Primary source
HGNC:HGNC:30381
See related
Ensembl:ENSG00000141295 MIM:614966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ses2
Expression
Ubiquitous expression in fat (RPKM 52.8), kidney (RPKM 36.1) and 25 other tissues See more
Orthologs
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Genomic context

See SCRN2 in Genome Data Viewer
Location:
17q21.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47837691..47841292, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45915058..45918639, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 7 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene leucine rich repeat containing 46 Neighboring gene Sp6 transcription factor Neighboring gene CRISPRi-validated cis-regulatory element chr17.3281 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
secernin-2
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145023.2NP_001138495.1  secernin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame segment in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC003665, AW452880, BC002980
    Consensus CDS
    CCDS45723.1
    UniProtKB/Swiss-Prot
    Q96FV2
    Related
    ENSP00000383935.3, ENST00000407215.7
    Conserved Domains (1) summary
    cl00467
    Location:21231
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_138355.4NP_612364.2  secernin-2 isoform 1

    See identical proteins and their annotated locations for NP_612364.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC003665, AW452880, BC010408, CN480733
    Consensus CDS
    CCDS11519.1
    UniProtKB/Swiss-Prot
    Q96FV2
    Related
    ENSP00000290216.9, ENST00000290216.14
    Conserved Domains (1) summary
    cl00467
    Location:21231
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47837691..47841292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025286.1XP_016880775.1  secernin-2 isoform X2

  2. XM_005257776.5XP_005257833.1  secernin-2 isoform X1

    See identical proteins and their annotated locations for XP_005257833.1

    UniProtKB/Swiss-Prot
    Q96FV2
    Conserved Domains (1) summary
    cl00467
    Location:21231
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. XM_024451019.1XP_024306787.1  secernin-2 isoform X3

RNA

  1. XR_934593.1 RNA Sequence

    Related
    ENST00000581645.5
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