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Mrm1 mitochondrial rRNA methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 217038, updated on 5-Mar-2024

Summary

Official Symbol
Mrm1provided by MGI
Official Full Name
mitochondrial rRNA methyltransferase 1provided by MGI
Primary source
MGI:MGI:2443470
See related
Ensembl:ENSMUSG00000018405 AllianceGenome:MGI:2443470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A530065E19Rik
Summary
Predicted to enable rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within methylation and rRNA processing. Located in mitochondrion. Orthologous to human MRM1 (mitochondrial rRNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 14.2), liver E14 (RPKM 12.8) and 28 other tissues See more
Orthologs
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Genomic context

See Mrm1 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84703887..84710341, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84813061..84819515, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30221 Neighboring gene RIKEN cDNA 1700109G15 gene Neighboring gene STARR-seq mESC enhancer starr_30223 Neighboring gene STARR-seq mESC enhancer starr_30224 Neighboring gene STARR-positive B cell enhancer ABC_E3984 Neighboring gene STARR-positive B cell enhancer ABC_E375 Neighboring gene STARR-positive B cell enhancer ABC_E3985 Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene dehydrogenase/reductase 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables rRNA (guanosine-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rRNA methyltransferase 1, mitochondrial
Names
16S rRNA (guanosine(1145)-2'-O)-methyltransferase
16S rRNA [Gm1145] 2'-O-methyltransferase
mitochondrial large ribosomal RNA ribose methylase
mitochondrial rRNA methyltransferase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145433.1NP_663408.2  rRNA methyltransferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663408.2

    Status: VALIDATED

    Source sequence(s)
    BC005625
    Consensus CDS
    CCDS36260.1
    UniProtKB/Swiss-Prot
    Q3TPX8, Q3U0Z5, Q5ND22, Q99J25
    Related
    ENSMUSP00000018549.8, ENSMUST00000018549.8
    Conserved Domains (2) summary
    cd18105
    Location:144301
    SpoU-like_MRM1; SAM-dependent rRNA methylase related to MRM1
    pfam08032
    Location:85125
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84703887..84710341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)