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MRM1 mitochondrial rRNA methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 79922, updated on 21-Dec-2019

Summary

Official Symbol
MRM1provided by HGNC
Official Full Name
mitochondrial rRNA methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:26202
See related
Ensembl:ENSG00000278619 MIM:618099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 1.2), lymph node (RPKM 1.0) and 25 other tissues See more
Orthologs

Genomic context

See MRM1 in Genome Data Viewer
Location:
17q12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36601583..36634698)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34958010..34965407)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11 Neighboring gene VISTA enhancer hs362 Neighboring gene uncharacterized LOC105371750 Neighboring gene uncharacterized LOC105371751

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA (guanosine-2'-O-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
rRNA 2'-O-methylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
rRNA methyltransferase 1, mitochondrial
Names
16S rRNA (guanosine(1145)-2'-O)-methyltransferase
16S rRNA [Gm1145] 2'-O-methyltransferase
CTB-75G16.3
mitochondrial large ribosomal RNA ribose methylase
mitochondrial rRNA methyltransferase 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024864.5NP_079140.2  rRNA methyltransferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079140.2

    Status: VALIDATED

    Source sequence(s)
    AC243732, BC009416, CB137408
    Consensus CDS
    CCDS32631.1
    UniProtKB/Swiss-Prot
    Q6IN84
    Related
    ENSP00000481559.1, ENST00000614766.5
    Conserved Domains (1) summary
    COG0566
    Location:40308
    SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36601583..36634698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525275.3XP_011523577.1  rRNA methyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011523577.1

    Conserved Domains (3) summary
    COG0566
    Location:40296
    SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]
    pfam00588
    Location:148296
    SpoU_methylase; SpoU rRNA Methylase family
    pfam08032
    Location:51127
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding
  2. XM_011525276.3XP_011523578.1  rRNA methyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011523578.1

    Conserved Domains (3) summary
    COG0566
    Location:40296
    SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]
    pfam00588
    Location:148296
    SpoU_methylase; SpoU rRNA Methylase family
    pfam08032
    Location:51127
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding
  3. XM_017025112.2XP_016880601.1  rRNA methyltransferase 1, mitochondrial isoform X1

  4. XM_005257694.5XP_005257751.1  rRNA methyltransferase 1, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_005257751.1

    Conserved Domains (2) summary
    pfam08032
    Location:51127
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding
    cl21505
    Location:148212
    SpoU_methylase; SpoU rRNA Methylase family

RNA

  1. XR_934554.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    837077..844465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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