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Neurl4 neuralized E3 ubiquitin protein ligase 4 [ Mus musculus (house mouse) ]

Gene ID: 216860, updated on 2-Nov-2024

Summary

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Official Symbol
Neurl4provided by MGI
Official Full Name
neuralized E3 ubiquitin protein ligase 4provided by MGI
Primary source
MGI:MGI:1921092
See related
Ensembl:ENSMUSG00000047284 AllianceGenome:MGI:1921092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within mitochondrial DNA repair and spermatogenesis. Predicted to be located in centriole and mitochondrion. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 24.9), CNS E14 (RPKM 22.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Neurl4 in Genome Data Viewer
Location:
11 B3; 11 42.92 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69792545..69804648)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69901727..69913824)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 6924 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69708255-69708446 Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene STARR-positive B cell enhancer ABC_E5243 Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene G protein pathway suppressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Cardamone MD, et al. J Cell Biol, 2022 Mar 7. PMID 35157000, Free PMC Article
  2. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Valnegri P, et al. Nat Commun, 2017 Nov 2. PMID 29097665, Free PMC Article
  3. Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Xing L, et al. Cell Rep, 2023 Jul 25. PMID 37389991, Free PMC Article
  4. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. Imai Y, et al. PLoS Genet, 2015 Sep. PMID 26355680, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1787, MGC189889, 0610025P10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuralized-like protein 4
Names
neuralized homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013414.4 → NP_001013432.1  neuralized-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001013432.1

    Status: VALIDATED

    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS24921.1
    UniProtKB/Swiss-Prot
    Q3U090, Q5NCX4, Q5NCX5, Q69ZA2, Q8R1V5
    UniProtKB/TrEMBL
    B2RY59
    Related
    ENSMUSP00000053235.5, ENSMUST00000061837.11
    Conserved Domains (2) summary
    smart00588
    Location:318 → 439
    NEUZ; domain in neuralized proteins
    cd12887
    Location:525 → 686
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  2. NM_001291118.2 → NP_001278047.1  neuralized-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS70220.1
    UniProtKB/TrEMBL
    B2RY59, H3BJZ3
    Related
    ENSMUSP00000135185.2, ENSMUST00000177476.8
    Conserved Domains (2) summary
    smart00588
    Location:318 → 439
    NEUZ; domain in neuralized proteins
    cd12887
    Location:720 → 882
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  3. NM_001291119.2 → NP_001278048.1  neuralized-like protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS70221.1
    UniProtKB/TrEMBL
    B7ZWP0, H3BK72
    Related
    ENSMUSP00000135277.2, ENSMUST00000177138.8
    Conserved Domains (2) summary
    smart00588
    Location:296 → 417
    NEUZ; domain in neuralized proteins
    cd12887
    Location:698 → 860
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69792545..69804648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532909.3 → XP_006532972.1  neuralized-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006532972.1

    UniProtKB/TrEMBL
    B2RY59
    Conserved Domains (1) summary
    cd12887
    Location:525 → 686
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  2. XM_017314458.2 → XP_017169947.1  neuralized-like protein 4 isoform X1

    UniProtKB/TrEMBL
    B7ZWP0
    Related
    ENSMUSP00000104257.4, ENSMUST00000108617.10
    Conserved Domains (1) summary
    cd12887
    Location:503 → 664
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  3. XM_036156572.1 → XP_036012465.1  neuralized-like protein 4 isoform X3

    UniProtKB/TrEMBL
    B2RY59
    Conserved Domains (1) summary
    cd12887
    Location:279 → 440
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

  4. XM_006532911.1 → XP_006532974.1  neuralized-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006532974.1

    Conserved Domains (1) summary
    cd12887
    Location:16 → 180
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RNA

  1. XR_001779952.3 RNA Sequence

  2. XR_001779951.3 RNA Sequence

  3. XR_388403.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCX5.1 GenPept UniProtKB/Swiss-Prot:Q5NCX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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