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NEURL4 neuralized E3 ubiquitin protein ligase 4 [ Homo sapiens (human) ]

Gene ID: 84461, updated on 23-Nov-2021

Summary

Official Symbol
NEURL4provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 4provided by HGNC
Primary source
HGNC:HGNC:34410
See related
Ensembl:ENSG00000215041 MIM:615865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

See NEURL4 in Genome Data Viewer
Location:
17p13.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7315628..7329335, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7218947..7232654, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene G protein pathway suppressor 2 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GPS2

Homology

Clone Names

  • FLJ35680, KIAA1787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuralized-like protein 4
Names
neuralized homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005408.2NP_001005408.1  neuralized-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame 6-nt segment in the coding region, as compared to variant 1. The encoded isoform 2 is thus slightly shorter than isoform 1.
    Source sequence(s)
    AB058690, AC026954, AL136870
    Consensus CDS
    CCDS42252.1
    UniProtKB/Swiss-Prot
    Q96JN8
    Related
    ENSP00000319826.7, ENST00000315614.11
    Conserved Domains (2) summary
    smart00588
    Location:316437
    NEUZ; domain in neuralized proteins
    cd12887
    Location:718880
    SPRY_NHR_like; SPRY domain in neuralized homology repeat
  2. NM_032442.3NP_115818.2  neuralized-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_115818.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB058690, AC026954, AL136870
    Consensus CDS
    CCDS42251.1
    UniProtKB/Swiss-Prot
    Q96JN8
    Related
    ENSP00000382390.2, ENST00000399464.7
    Conserved Domains (2) summary
    smart00588
    Location:316437
    NEUZ; domain in neuralized proteins
    cd12887
    Location:523684
    SPRY_NHR_like; SPRY domain in neuralized homology repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7315628..7329335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    73993..87700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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