Format

Send to:

Choose Destination

Tef thyrotroph embryonic factor [ Mus musculus (house mouse) ]

Gene ID: 21685, updated on 12-Aug-2019

Summary

Official Symbol
Tefprovided by MGI
Official Full Name
thyrotroph embryonic factorprovided by MGI
Primary source
MGI:MGI:98663
See related
Ensembl:ENSMUSG00000022389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310028D20Rik
Expression
Broad expression in cortex adult (RPKM 46.8), bladder adult (RPKM 43.9) and 24 other tissues See more
Orthologs

Genomic context

See Tef in Genome Data Viewer
Location:
15 E1; 15 38.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81802673..81826863)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81633103..81657293)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 7B Neighboring gene predicted gene, 17597 Neighboring gene predicted gene 8444 Neighboring gene transducer of ERBB2, 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thyrotroph embryonic factor
Names
thyrotrophic embryonic factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017376.3NP_059072.1  thyrotroph embryonic factor isoform 1

    See identical proteins and their annotated locations for NP_059072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147965, AY540631, BP764162, BY336350
    Consensus CDS
    CCDS27672.1
    UniProtKB/Swiss-Prot
    Q9JLC6
    Related
    ENSMUSP00000023024.7, ENSMUST00000023024.7
    Conserved Domains (1) summary
    cd14695
    Location:230288
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. NM_153484.3NP_705617.2  thyrotroph embryonic factor isoform 2

    See identical proteins and their annotated locations for NP_705617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' coding exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK141606, AK147965, BP764162, BY296040
    Consensus CDS
    CCDS27671.2
    UniProtKB/Swiss-Prot
    Q9JLC6
    Related
    ENSMUSP00000105180.2, ENSMUST00000109553.9
    Conserved Domains (1) summary
    cd14695
    Location:214272
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

    Range
    81802673..81826863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245558.3XP_011243860.1  thyrotroph embryonic factor isoform X2

    See identical proteins and their annotated locations for XP_011243860.1

    Conserved Domains (1) summary
    cd14695
    Location:253311
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. XM_011245560.3XP_011243862.1  thyrotroph embryonic factor isoform X3

    See identical proteins and their annotated locations for XP_011243862.1

    Conserved Domains (1) summary
    cd14695
    Location:200258
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  3. XM_006520744.2XP_006520807.1  thyrotroph embryonic factor isoform X4

    Conserved Domains (1) summary
    cd14695
    Location:161219
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  4. XM_011245557.3XP_011243859.1  thyrotroph embryonic factor isoform X1

    Conserved Domains (1) summary
    cd14695
    Location:269327
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  5. XM_030248461.1XP_030104321.1  thyrotroph embryonic factor isoform X5

  6. XM_011245559.2XP_011243861.1  thyrotroph embryonic factor isoform X3

    See identical proteins and their annotated locations for XP_011243861.1

    Conserved Domains (1) summary
    cd14695
    Location:200258
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  7. XM_030248460.1XP_030104320.1  thyrotroph embryonic factor isoform X4

Support Center