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Tef thyrotroph embryonic factor [ Mus musculus (house mouse) ]

Gene ID: 21685, updated on 2-Nov-2024

Summary

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Official Symbol
Tefprovided by MGI
Official Full Name
thyrotroph embryonic factorprovided by MGI
Primary source
MGI:MGI:98663
See related
Ensembl:ENSMUSG00000022389 AllianceGenome:MGI:98663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310028D20Rik
Summary
Enables double-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; early conceptus; genitourinary system; and trunk somite. Orthologous to human TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 46.8), bladder adult (RPKM 43.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tef in Genome Data Viewer
Location:
15 E1; 15 38.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81686874..81711064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81802673..81826863)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 7B Neighboring gene STARR-seq mESC enhancer starr_39269 Neighboring gene predicted gene, 17597 Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene STARR-positive B cell enhancer ABC_E8940 Neighboring gene STARR-positive B cell enhancer ABC_E8599 Neighboring gene predicted gene 8444 Neighboring gene STARR-positive B cell enhancer ABC_E7399 Neighboring gene STARR-positive B cell enhancer ABC_E481 Neighboring gene transducer of ERBB2, 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway. Yang J, et al. Cell Prolif, 2019 Mar. PMID 30515906, Free PMC Article
  2. The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences. Fonjallaz P, et al. EMBO J, 1996 Jan 15. PMID 8617210, Free PMC Article
  3. Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression. Krueger DA, et al. J Biol Chem, 2000 May 12. PMID 10799536
  4. Activation of the smooth muscle-specific telokin gene by thyrotroph embryonic factor (TEF). Zhou J, et al. J Biol Chem, 2004 Apr 16. PMID 14702338
  5. PAR bZIP-bik is a novel transcriptional pathway that mediates oxidative stress-induced apoptosis in fibroblasts. Ritchie A, et al. Cell Death Differ, 2009 Jun. PMID 19219069

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of TEF expression significantly retarded Bladder Cancer cell growth by inhibiting the G1/S transition via regulating AKT/FOXOs signalling.
    Title: Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway.
  2. In Ccdc80(-/-) mice, expression of the core clock member Arntl/Bmal1 was reduced whereas that of the oscillating transcription factors Dbp and Tef was increased in all tissues examined.
    Title: Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
  3. evidence of TEF regulation through a miR-125b-mediated pathway
    Title: A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts.
  4. Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group.
    Title: Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
  5. we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
    Title: Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
  6. Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
    Title: Molecular clock is involved in predictive circadian adjustment of renal function.
  7. mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain
    Title: The loss of circadian PAR bZip transcription factors results in epilepsy.
  8. TEF contributes to the activation of the telokin promoter in smooth muscle cells in a calcium-dependent manner
    Title: Activation of the smooth muscle-specific telokin gene by thyrotroph embryonic factor (TEF).
  9. The Tef protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
    Title: The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thyrotroph embryonic factor
Names
thyrotrophic embryonic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017376.3 → NP_059072.1  thyrotroph embryonic factor isoform 1

    See identical proteins and their annotated locations for NP_059072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147965, AY540631, BP764162, BY336350
    Consensus CDS
    CCDS27672.1
    UniProtKB/Swiss-Prot
    Q3U426, Q3UGF4, Q3UM49, Q3URC8, Q6QHT6, Q8C6I0, Q8VD02, Q9JLC6
    UniProtKB/TrEMBL
    Q3V3B6
    Related
    ENSMUSP00000023024.8, ENSMUST00000023024.8
    Conserved Domains (1) summary
    cd14695
    Location:230 → 288
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  2. NM_153484.3 → NP_705617.2  thyrotroph embryonic factor isoform 2

    See identical proteins and their annotated locations for NP_705617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' coding exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK141606, AK147965, BP764162, BY296040
    Consensus CDS
    CCDS27671.2
    UniProtKB/TrEMBL
    Q3V3B6
    Related
    ENSMUSP00000105180.3, ENSMUST00000109553.10
    Conserved Domains (1) summary
    cd14695
    Location:214 → 272
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81686874..81711064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245558.4 → XP_011243860.1  thyrotroph embryonic factor isoform X2

    See identical proteins and their annotated locations for XP_011243860.1

    UniProtKB/TrEMBL
    Q3V3B6
    Conserved Domains (1) summary
    cd14695
    Location:253 → 311
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  2. XM_011245557.4 → XP_011243859.1  thyrotroph embryonic factor isoform X1

    Conserved Domains (1) summary
    cd14695
    Location:269 → 327
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  3. XM_011245560.3 → XP_011243862.1  thyrotroph embryonic factor isoform X3

    See identical proteins and their annotated locations for XP_011243862.1

    UniProtKB/TrEMBL
    Q3V3B6
    Conserved Domains (1) summary
    cd14695
    Location:200 → 258
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  4. XM_006520744.2 → XP_006520807.1  thyrotroph embryonic factor isoform X4

    UniProtKB/TrEMBL
    Q3V3B6
    Conserved Domains (1) summary
    cd14695
    Location:161 → 219
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  5. XM_036159316.1 → XP_036015209.1  thyrotroph embryonic factor isoform X6

    Conserved Domains (1) summary
    cd14695
    Location:110 → 168
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  6. XM_030248461.2 → XP_030104321.1  thyrotroph embryonic factor isoform X6

    Conserved Domains (1) summary
    cd14695
    Location:110 → 168
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  7. XM_011245559.3 → XP_011243861.1  thyrotroph embryonic factor isoform X3

    See identical proteins and their annotated locations for XP_011243861.1

    UniProtKB/TrEMBL
    Q3V3B6
    Conserved Domains (1) summary
    cd14695
    Location:200 → 258
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  8. XM_030248460.2 → XP_030104320.1  thyrotroph embryonic factor isoform X4

    UniProtKB/TrEMBL
    Q3V3B6
    Conserved Domains (1) summary
    cd14695
    Location:161 → 219
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  9. XM_036159315.1 → XP_036015208.1  thyrotroph embryonic factor isoform X5

    Conserved Domains (1) summary
    cd14695
    Location:119 → 177
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLC6.1 GenPept UniProtKB/Swiss-Prot:Q9JLC6

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