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TEF TEF transcription factor, PAR bZIP family member [ Homo sapiens (human) ]

Gene ID: 7008, updated on 12-Oct-2019

Summary

Official Symbol
TEFprovided by HGNC
Official Full Name
TEF transcription factor, PAR bZIP family memberprovided by HGNC
Primary source
HGNC:HGNC:11722
See related
Ensembl:ENSG00000167074 MIM:188595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in brain (RPKM 21.5), ovary (RPKM 19.9) and 24 other tissues See more
Orthologs

Genomic context

See TEF in Genome Data Viewer
Location:
22q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41367333..41399328)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41763337..41795332)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Ran GTPase activating protein 1 Neighboring gene Sharpr-MPRA regulatory region 14092 Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene uncharacterized LOC100996598 Neighboring gene uncharacterized LOC105373042 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene HNF4 motif-containing MPRA enhancer 178 Neighboring gene uncharacterized LOC105373043 Neighboring gene transducer of ERBB2, 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1655

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
thyrotroph embryonic factor
Names
TEF, PAR bZIP transcription factor
thyrotrophic embryonic factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145398.2NP_001138870.1  thyrotroph embryonic factor isoform 2

    See identical proteins and their annotated locations for NP_001138870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL008582, AL035659, BX537848, DA213449, DA243618, R38583
    Consensus CDS
    CCDS46716.1
    UniProtKB/Swiss-Prot
    Q10587
    Related
    ENSP00000385256.3, ENST00000406644.7
    Conserved Domains (1) summary
    cd14695
    Location:202260
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
  2. NM_003216.4NP_003207.1  thyrotroph embryonic factor isoform 1

    See identical proteins and their annotated locations for NP_003207.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL008582, AL035659, DA238847, R38583, U44059
    Consensus CDS
    CCDS14014.1
    UniProtKB/Swiss-Prot
    Q10587
    Related
    ENSP00000266304.4, ENST00000266304.9
    Conserved Domains (1) summary
    cd14695
    Location:232290
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    41367333..41399328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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