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Usp43 ubiquitin specific peptidase 43 [ Mus musculus (house mouse) ]

Gene ID: 216835, updated on 5-Mar-2024

Summary

Official Symbol
Usp43provided by MGI
Official Full Name
ubiquitin specific peptidase 43provided by MGI
Primary source
MGI:MGI:2444541
See related
Ensembl:ENSMUSG00000020905 AllianceGenome:MGI:2444541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis. Orthologous to human USP43 (ubiquitin specific peptidase 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 9.8), large intestine adult (RPKM 7.0) and 17 other tissues See more
Orthologs
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Genomic context

Location:
11 B3; 11 41.13 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67745349..67812979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67854523..67922153, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 7C Neighboring gene predicted gene, 40032 Neighboring gene cilia and flagella associated protein 52 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L31 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Clone Names

  • 9130017K11Rik, C630032K07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 43
Names
deubiquitinating enzyme 43
ubiquitin thioesterase 43
ubiquitin thiolesterase 43
ubiquitin-specific-processing protease 43
NP_001277978.1
NP_776115.2
XP_011247217.1
XP_017169942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291049.1NP_001277978.1  ubiquitin carboxyl-terminal hydrolase 43 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK042217, AK083271, AL732570
    Consensus CDS
    CCDS70212.1
    UniProtKB/TrEMBL
    A6PWR8
    Related
    ENSMUSP00000104317.2, ENSMUST00000108677.2
    Conserved Domains (2) summary
    cd02674
    Location:536703
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:102284
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. NM_173754.4NP_776115.2  ubiquitin carboxyl-terminal hydrolase 43 isoform 1

    See identical proteins and their annotated locations for NP_776115.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK042217, AK083271, AL732570
    Consensus CDS
    CCDS24861.2
    UniProtKB/Swiss-Prot
    Q8BUM9, Q8VDP5
    Related
    ENSMUSP00000021288.4, ENSMUST00000021288.10
    Conserved Domains (2) summary
    cd02674
    Location:536708
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:102284
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67745349..67812979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248915.4XP_011247217.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X1

    Conserved Domains (1) summary
    cd02674
    Location:225397
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  2. XM_017314453.2XP_017169942.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X2

    Conserved Domains (1) summary
    cd02674
    Location:93265
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...