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USP43 ubiquitin specific peptidase 43 [ Homo sapiens (human) ]

Gene ID: 124739, updated on 8-Jul-2021

Summary

Official Symbol
USP43provided by HGNC
Official Full Name
ubiquitin specific peptidase 43provided by HGNC
Primary source
HGNC:HGNC:20072
See related
Ensembl:ENSG00000154914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in placenta (RPKM 3.1), prostate (RPKM 3.0) and 19 other tissues See more
Orthologs
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Genomic context

See USP43 in Genome Data Viewer
Location:
17p13.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (9643493..9729687)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (9548834..9633004)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L19 pseudogene 18 Neighboring gene cilia and flagella associated protein 52 Neighboring gene uncharacterized LOC107985011 Neighboring gene DHRS7C intron CAGE-defined high expression enhancer Neighboring gene dehydrogenase/reductase 7C Neighboring gene GSG1 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30626

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ISG15-specific protease activity TAS
Traceable Author Statement
more info
 
enables thiol-dependent deubiquitinase IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in translesion synthesis TAS
Traceable Author Statement
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 43
Names
deubiquitinating enzyme 43
ubiquitin specific protease 43
ubiquitin thioesterase 43
ubiquitin thiolesterase 43
ubiquitin-specific-processing protease 43
NP_001254505.1
NP_694942.3
XP_011521941.1
XP_011521942.1
XP_011521943.1
XP_011521944.1
XP_016879648.1
XP_016879649.1
XP_016879650.1
XP_016879651.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267576.2NP_001254505.1  ubiquitin carboxyl-terminal hydrolase 43 isoform 2

    See identical proteins and their annotated locations for NP_001254505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC118755, AJ583817, BC039653, BC136368
    Consensus CDS
    CCDS58516.1
    UniProtKB/Swiss-Prot
    Q70EL4
    Related
    ENSP00000458963.1, ENST00000570475.5
    Conserved Domains (3) summary
    cd02674
    Location:540703
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:102284
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam12300
    Location:36107
    DUF3628; Protein of unknown function (DUF3628)
  2. NM_153210.5NP_694942.3  ubiquitin carboxyl-terminal hydrolase 43 isoform 1

    See identical proteins and their annotated locations for NP_694942.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118755, AJ583817, BC039653, BC144041
    Consensus CDS
    CCDS45610.1
    UniProtKB/Swiss-Prot
    Q70EL4
    Related
    ENSP00000285199.6, ENST00000285199.12
    Conserved Domains (3) summary
    cd02674
    Location:540708
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:102284
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam12300
    Location:36107
    DUF3628; Protein of unknown function (DUF3628)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    9643493..9729687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523641.1XP_011521943.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X2

    See identical proteins and their annotated locations for XP_011521943.1

    Related
    ENSP00000459328.3, ENST00000574408.5
    Conserved Domains (3) summary
    COG5560
    Location:32508
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:337505
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:4481
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_011523642.3XP_011521944.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X3

    See identical proteins and their annotated locations for XP_011521944.1

    UniProtKB/Swiss-Prot
    Q70EL4
    Related
    ENST00000570827.6
    Conserved Domains (2) summary
    cd02674
    Location:229397
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:230396
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_017024162.2XP_016879651.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X4

  4. XM_017024159.2XP_016879648.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X2

    Conserved Domains (3) summary
    COG5560
    Location:32508
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:337505
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:4481
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  5. XM_011523639.2XP_011521941.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X1

    Conserved Domains (3) summary
    cd02674
    Location:509677
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:102221
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam12300
    Location:36107
    DUF3628; Protein of unknown function (DUF3628)
  6. XM_011523640.1XP_011521942.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X2

    See identical proteins and their annotated locations for XP_011521942.1

    Conserved Domains (3) summary
    COG5560
    Location:32508
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:337505
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:4481
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  7. XM_017024160.1XP_016879649.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X3

    UniProtKB/Swiss-Prot
    Q70EL4
    Conserved Domains (2) summary
    cd02674
    Location:229397
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:230396
    UCH; Ubiquitin carboxyl-terminal hydrolase
  8. XM_017024161.1XP_016879650.1  ubiquitin carboxyl-terminal hydrolase 43 isoform X3

    UniProtKB/Swiss-Prot
    Q70EL4
    Conserved Domains (2) summary
    cd02674
    Location:229397
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:230396
    UCH; Ubiquitin carboxyl-terminal hydrolase
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