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Tead1 TEA domain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 21676, updated on 5-Feb-2019

Summary

Official Symbol
Tead1provided by MGI
Official Full Name
TEA domain family member 1provided by MGI
Primary source
MGI:MGI:101876
See related
Ensembl:ENSMUSG00000055320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik
Expression
Broad expression in bladder adult (RPKM 16.6), heart adult (RPKM 14.4) and 24 other tissues See more
Orthologs

Genomic context

See Tead1 in Genome Data Viewer
Location:
7; 7 F1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (112679320..112906805)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (119822834..120050319)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310014F06 gene Neighboring gene predicted gene, 40451 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulator recruiting activity ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
embryonic heart tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
lateral mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
notochord development IGI
Inferred from Genetic Interaction
more info
PubMed 
paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
TEAD-1-YAP complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IC
Inferred by Curator
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-1
Names
NTEF-1
TCF-13
transcription factor 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166584.1NP_001160056.1  transcriptional enhancer factor TEF-1 isoform 1

    See identical proteins and their annotated locations for NP_001160056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC104930, AK140307
    Consensus CDS
    CCDS52365.1
    UniProtKB/TrEMBL
    Q3USK5
    Related
    ENSMUSP00000060671.9, ENSMUST00000059768.16
    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  2. NM_001166585.1NP_001160057.1  transcriptional enhancer factor TEF-1 isoform 3

    See identical proteins and their annotated locations for NP_001160057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The promoter and splice pattern of the 5' UTR has not been determined. The resulting isoform (3) lacks two internal segments, compared to variant 1.
    Source sequence(s)
    AC104930, AK140307, BC052021
    Consensus CDS
    CCDS52367.1
    UniProtKB/TrEMBL
    Q3USK5, Q6PAQ8, Q80W05
    Related
    ENSMUSP00000130459.2, ENSMUST00000069256.11
    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  3. NM_009346.3NP_033372.1  transcriptional enhancer factor TEF-1 isoform 2

    See identical proteins and their annotated locations for NP_033372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC104930, AK140307, AK148375
    Consensus CDS
    CCDS52366.1
    UniProtKB/Swiss-Prot
    P30051
    UniProtKB/TrEMBL
    Q3UFP5, Q3USK5
    Related
    ENSMUSP00000102249.2, ENSMUST00000106638.8
    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    112679320..112906805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507563.2XP_006507626.1  transcriptional enhancer factor TEF-1 isoform X3

    See identical proteins and their annotated locations for XP_006507626.1

    UniProtKB/TrEMBL
    Q6PAQ8
    Related
    ENSMUSP00000081755.5, ENSMUST00000084705.11
    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  2. XM_006507561.2XP_006507624.1  transcriptional enhancer factor TEF-1 isoform X1

    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  3. XM_006507562.2XP_006507625.1  transcriptional enhancer factor TEF-1 isoform X2

    UniProtKB/TrEMBL
    E9PZ73
    Related
    ENSMUSP00000131221.1, ENSMUST00000165036.7
    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  4. XM_011241723.1XP_011240025.1  transcriptional enhancer factor TEF-1 isoform X4

    Conserved Domains (1) summary
    smart00426
    Location:1582
    TEA; TEA domain
  5. XM_006507564.2XP_006507627.1  transcriptional enhancer factor TEF-1 isoform X5

    UniProtKB/TrEMBL
    E9PVS2
    Related
    ENSMUSP00000133025.1, ENSMUST00000168981.7
    Conserved Domains (1) summary
    smart00426
    Location:1580
    TEA; TEA domain
  6. XM_006507565.2XP_006507628.1  transcriptional enhancer factor TEF-1 isoform X6

    UniProtKB/TrEMBL
    E9Q387
    Related
    ENSMUSP00000129798.1, ENSMUST00000170352.7
    Conserved Domains (1) summary
    smart00426
    Location:1574
    TEA; TEA domain
  7. XM_011241724.1XP_011240026.1  transcriptional enhancer factor TEF-1 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175559.2: Suppressed sequence

    Description
    NM_175559.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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