Format

Send to:

Choose Destination

TEAD1 TEA domain transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 7003, updated on 1-Jun-2020

Summary

Official Symbol
TEAD1provided by HGNC
Official Full Name
TEA domain transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:11714
See related
Ensembl:ENSG00000187079 MIM:189967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
Summary
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues See more
Orthologs

Genomic context

See TEAD1 in Genome Data Viewer
Location:
11p15.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (12674421..12944737)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12695969..12966284)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene parvin alpha Neighboring gene uncharacterized LOC105376556 Neighboring gene TEAD1 intron CAGE-defined low expression enhancers Neighboring gene uncharacterized LOC107984313 Neighboring gene VISTA enhancer hs1314 Neighboring gene long intergenic non-protein coding RNA 958 Neighboring gene RASSF10 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Sveinsson chorioretinal atrophy
MedGen: C1862382 OMIM: 108985 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17970

Gene Ontology Provided by GOA

Process Evidence Code Pubs
embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
TEAD-1-YAP complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-1
Names
TEA domain family member 1 (SV40 transcriptional enhancer factor)
protein GT-IIC
transcription factor 13
transcriptional enhancer factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021302.1 RefSeqGene

    Range
    5000..275316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021961.6NP_068780.2  transcriptional enhancer factor TEF-1

    See identical proteins and their annotated locations for NP_068780.2

    Status: REVIEWED

    Source sequence(s)
    AB209858, AC107881, BC115398, BG720371, BU172369, CA420177, CN420966, DR000961
    Consensus CDS
    CCDS7810.2
    UniProtKB/Swiss-Prot
    P28347
    UniProtKB/TrEMBL
    Q59EF3
    Related
    ENSP00000435233.1, ENST00000527636.6
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    12674421..12944737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center