U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ccdc157 coiled-coil domain containing 157 [ Mus musculus (house mouse) ]

Gene ID: 216516, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ccdc157provided by MGI
Official Full Name
coiled-coil domain containing 157provided by MGI
Primary source
MGI:MGI:3041210
See related
Ensembl:ENSMUSG00000051427 AllianceGenome:MGI:3041210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1656; 4930562D19Rik
Summary
Used to study oligoasthenoteratozoospermia. Orthologous to human CCDC157 (coiled-coil domain containing 157). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 13.6), ovary adult (RPKM 8.8) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ccdc157 in Genome Data Viewer
Location:
11 A1; 11 2.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4091123..4110999, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4141123..4160293, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060 Neighboring gene splicing factor 3a, subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E727 Neighboring gene TBC1 domain family, member 10a Neighboring gene STARR-positive B cell enhancer ABC_E2978 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men. Zheng H, et al. J Cell Mol Med, 2024 Apr. PMID 38509755, Free PMC Article
  2. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
coiled-coil domain-containing protein 157

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164620.1 → NP_001158092.1  coiled-coil domain-containing protein 157 isoform 1

    See identical proteins and their annotated locations for NP_001158092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AK133165, AL807825
    Consensus CDS
    CCDS48743.1
    UniProtKB/Swiss-Prot
    Q0P531, Q3V0G5, Q5DTW1, Q5SPX1, Q8C5Y5
    Related
    ENSMUSP00000091074.5, ENSMUST00000093381.11
    Conserved Domains (2) summary
    COG1196
    Location:281 → 541
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:520 → 681
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  2. NM_177616.3 → NP_808284.2  coiled-coil domain-containing protein 157 isoform 2

    See identical proteins and their annotated locations for NP_808284.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK133165, AK220409, AL807825
    Consensus CDS
    CCDS24379.1
    UniProtKB/Swiss-Prot
    Q5SPX1
    Related
    ENSMUSP00000099148.3, ENSMUST00000101626.9
    Conserved Domains (2) summary
    COG1196
    Location:179 → 439
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:418 → 579
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4091123..4110999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156515.1 → XP_036012408.1  coiled-coil domain-containing protein 157 isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:179 → 439
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:418 → 579
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  2. XM_036156516.1 → XP_036012409.1  coiled-coil domain-containing protein 157 isoform X7

    Related
    ENSMUST00000137060.2
    Conserved Domains (2) summary
    COG1196
    Location:7 → 219
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:140 → 301
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  3. XM_011243677.4 → XP_011241979.1  coiled-coil domain-containing protein 157 isoform X5

    See identical proteins and their annotated locations for XP_011241979.1

    Conserved Domains (2) summary
    PRK13729
    Location:418 → 521
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    COG1196
    Location:178 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_036156514.1 → XP_036012407.1  coiled-coil domain-containing protein 157 isoform X4

    UniProtKB/Swiss-Prot
    Q0P531, Q3V0G5, Q5DTW1, Q5SPX1, Q8C5Y5
    Conserved Domains (2) summary
    COG1196
    Location:281 → 541
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:520 → 681
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  5. XM_011243675.4 → XP_011241977.1  coiled-coil domain-containing protein 157 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:280 → 558
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:520 → 623
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  6. XM_011243673.4 → XP_011241975.1  coiled-coil domain-containing protein 157 isoform X1

    See identical proteins and their annotated locations for XP_011241975.1

    Conserved Domains (2) summary
    PRK13729
    Location:531 → 634
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    COG1196
    Location:291 → 569
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006514618.5 → XP_006514681.1  coiled-coil domain-containing protein 157 isoform X3

    Conserved Domains (2) summary
    PRK13729
    Location:531 → 692
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    COG1196
    Location:292 → 552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_030245781.2 → XP_030101641.1  coiled-coil domain-containing protein 157 isoform X5

    Conserved Domains (2) summary
    PRK13729
    Location:418 → 521
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    COG1196
    Location:178 → 456
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. XM_036156513.1 → XP_036012406.1  coiled-coil domain-containing protein 157 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:280 → 558
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28929
    Location:520 → 623
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  10. XM_011243674.4 → XP_011241976.1  coiled-coil domain-containing protein 157 isoform X1

    See identical proteins and their annotated locations for XP_011241976.1

    Conserved Domains (2) summary
    PRK13729
    Location:531 → 634
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    COG1196
    Location:291 → 569
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SPX1.1 GenPept UniProtKB/Swiss-Prot:Q5SPX1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools