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CCDC157 coiled-coil domain containing 157 [ Homo sapiens (human) ]

Gene ID: 550631, updated on 23-Nov-2021

Summary

Official Symbol
CCDC157provided by HGNC
Official Full Name
coiled-coil domain containing 157provided by HGNC
Primary source
HGNC:HGNC:33854
See related
Ensembl:ENSG00000187860 MIM:619391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 7.5), kidney (RPKM 0.9) and 16 other tissues See more
Orthologs
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Genomic context

See CCDC157 in Genome Data Viewer
Location:
22q12.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30356624..30378673)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30752613..30774662)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene TBC1 domain family member 10A Neighboring gene origin of replication in TBC1D10A Neighboring gene splicing factor 3a subunit 1 Neighboring gene KIAA1656 protein Neighboring gene ring finger protein 215 Neighboring gene SEC14 like lipid binding 2 Neighboring gene uncharacterized LOC105372989 Neighboring gene RNA, U6 small nuclear 564, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetics of coronary artery calcification among African Americans, a meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017437.5NP_001017437.3  coiled-coil domain-containing protein 157 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC004997
    Consensus CDS
    CCDS33632.2
    Related
    ENSP00000343087.3, ENST00000338306.8
    Conserved Domains (2) summary
    PHA03247
    Location:630751
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:277522
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. NM_001318334.2NP_001305263.2  coiled-coil domain-containing protein 157 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC004997
    Consensus CDS
    CCDS33632.2
    Related
    ENSP00000385357.1, ENST00000405659.5
    Conserved Domains (2) summary
    PHA03247
    Location:630751
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:277522
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. NM_001318335.2NP_001305264.1  coiled-coil domain-containing protein 157 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004997, BC018040, DA647196
    Consensus CDS
    CCDS82707.1
    UniProtKB/TrEMBL
    A8MUK5
    Related
    ENSP00000382720.2, ENST00000399824.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30356624..30378673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530266.3XP_011528568.1  coiled-coil domain-containing protein 157 isoform X5

    Conserved Domains (2) summary
    pfam05816
    Location:426524
    TelA; Toxic anion resistance protein (TelA)
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  2. XM_024452258.1XP_024308026.1  coiled-coil domain-containing protein 157 isoform X1

    Conserved Domains (2) summary
    pfam05956
    Location:635730
    APC_basic; APC basic domain
    cl25732
    Location:277522
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_006724278.4XP_006724341.1  coiled-coil domain-containing protein 157 isoform X1

    See identical proteins and their annotated locations for XP_006724341.1

    Conserved Domains (2) summary
    pfam05956
    Location:635730
    APC_basic; APC basic domain
    cl25732
    Location:277522
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_006724279.4XP_006724342.1  coiled-coil domain-containing protein 157 isoform X2

    Conserved Domains (2) summary
    pfam05816
    Location:426524
    TelA; Toxic anion resistance protein (TelA)
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  5. XM_006724280.4XP_006724343.1  coiled-coil domain-containing protein 157 isoform X4

    Conserved Domains (2) summary
    pfam05816
    Location:426524
    TelA; Toxic anion resistance protein (TelA)
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  6. XM_024452259.1XP_024308027.1  coiled-coil domain-containing protein 157 isoform X3

    Conserved Domains (2) summary
    pfam05956
    Location:544639
    APC_basic; APC basic domain
    cl25732
    Location:186431
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_011530267.3XP_011528569.1  coiled-coil domain-containing protein 157 isoform X6

    Conserved Domains (2) summary
    pfam05816
    Location:426524
    TelA; Toxic anion resistance protein (TelA)
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  8. XM_011530268.3XP_011528570.1  coiled-coil domain-containing protein 157 isoform X7

    Conserved Domains (1) summary
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  9. XM_011530270.3XP_011528572.1  coiled-coil domain-containing protein 157 isoform X9

    Conserved Domains (1) summary
    cl03951
    Location:278367
    CDC37_N; Cdc37 N terminal kinase binding
  10. XM_011530263.3XP_011528565.1  coiled-coil domain-containing protein 157 isoform X1

    See identical proteins and their annotated locations for XP_011528565.1

    Conserved Domains (2) summary
    pfam05956
    Location:635730
    APC_basic; APC basic domain
    cl25732
    Location:277522
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_011530269.2XP_011528571.1  coiled-coil domain-containing protein 157 isoform X8

    Conserved Domains (1) summary
    pfam05816
    Location:70168
    TelA; Toxic anion resistance protein (TelA)
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