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Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [ Mus musculus (house mouse) ]

Gene ID: 216439, updated on 8-Feb-2024

Summary

Official Symbol
Agap2provided by MGI
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2provided by MGI
Primary source
MGI:MGI:3580016
See related
Ensembl:ENSMUSG00000025422 AllianceGenome:MGI:3580016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIKE; AGAP-2; Centg1; cnt-g1; mKIAA0167
Summary
The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
Expression
Biased expression in frontal lobe adult (RPKM 84.2), cortex adult (RPKM 70.9) and 8 other tissues See more
Orthologs
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Genomic context

See Agap2 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126911154..126929039)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127075269..127093170)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126500339-126500526 Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E582 Neighboring gene cyclin dependent kinase 4 Neighboring gene tetraspanin 31 Neighboring gene amplified in osteosarcoma Neighboring gene predicted gene, 40799 Neighboring gene STARR-positive B cell enhancer ABC_E253 Neighboring gene STARR-seq mESC enhancer starr_28206 Neighboring gene STARR-seq mESC enhancer starr_28208 Neighboring gene coenzyme Q4 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glycine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endosomal transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynapse IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Names
centaurin, gamma 1
phosphatidylinositol 3-kinase enhancer

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033263.5NP_001028435.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001028435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA189612, AC131760, AK147446
    Consensus CDS
    CCDS24228.1
    UniProtKB/Swiss-Prot
    Q3UHD9, Q5DU45
    Related
    ENSMUSP00000043466.7, ENSMUST00000039259.7
    Conserved Domains (8) summary
    cd04103
    Location:401560
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:399566
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:10771141
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:668908
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:839903
    PH; PH domain
    pfam01412
    Location:9271041
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:10721125
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:10841115
    ANK; ANK repeat [structural motif]
  2. NM_001301014.1NP_001287943.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001287943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA189612, AC131760, AK147446
    Consensus CDS
    CCDS88097.1
    UniProtKB/Swiss-Prot
    Q3UHD9
    Related
    ENSMUSP00000151946.2, ENSMUST00000217941.2
    Conserved Domains (8) summary
    cd04103
    Location:401560
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:399566
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:10571121
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:668888
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:846883
    PH; PH domain
    pfam01412
    Location:9071021
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:10521105
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:10641095
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126911154..126929039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513561.5XP_006513624.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006513624.1

    Conserved Domains (4) summary
    cd04103
    Location:71230
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:338578
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    cd08836
    Location:596703
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains
    pfam04592
    Location:806858
    SelP_N; Selenoprotein P, N terminal region
  2. XM_006513563.4XP_006513626.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006513626.1

    UniProtKB/TrEMBL
    A0A5F8MPB7
    Related
    ENSMUSP00000158894.2, ENSMUST00000239120.2
    Conserved Domains (5) summary
    cd04103
    Location:71230
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:338558
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:734765
    ANK; ANK repeat [structural motif]
    cd08836
    Location:576683
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains
    pfam12796
    Location:739791
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006513558.5XP_006513621.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006513621.1

    Conserved Domains (5) summary
    cd04103
    Location:401560
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PHA03247
    Location:52320
    PHA03247; large tegument protein UL36; Provisional
    cd01250
    Location:668908
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    cd08836
    Location:9261033
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains
    pfam04592
    Location:11361188
    SelP_N; Selenoprotein P, N terminal region
  4. XM_006513559.5XP_006513622.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006513622.1

    Conserved Domains (5) summary
    cd04103
    Location:401560
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PHA03247
    Location:52320
    PHA03247; large tegument protein UL36; Provisional
    cd01250
    Location:668888
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    cd08836
    Location:9061013
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains
    pfam04592
    Location:11161168
    SelP_N; Selenoprotein P, N terminal region
  5. XM_006513562.5XP_006513625.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006513625.1

    Conserved Domains (3) summary
    cd04103
    Location:401560
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PHA03247
    Location:52320
    PHA03247; large tegument protein UL36; Provisional
    cl17171
    Location:668739
    PH-like; Pleckstrin homology-like domain