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Socs2 suppressor of cytokine signaling 2 [ Mus musculus (house mouse) ]

Gene ID: 216233, updated on 17-Jan-2023

Summary

Official Symbol
Socs2provided by MGI
Official Full Name
suppressor of cytokine signaling 2provided by MGI
Primary source
MGI:MGI:1201787
See related
Ensembl:ENSMUSG00000020027 AllianceGenome:MGI:1201787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hg; JAB; CIS2; Cish2; SSI-2; SOCS-2; 8030460M17; D130043N08Rik
Summary
Enables growth hormone receptor binding activity. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including lung; primary sex cord; retina; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.8), lung adult (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

See Socs2 in Genome Data Viewer
Location:
10 C2; 10 49.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95219765..95253176, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95383903..95417321, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CASP2 and RIPK1 domain containing adaptor with death domain Neighboring gene RIKEN cDNA 2310039L15 gene Neighboring gene RIKEN cDNA 5730420D15 gene Neighboring gene predicted gene, 33230 Neighboring gene predicted gene 3619

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JAK pathway signal transduction adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
suppressor of cytokine signaling 2
Names
CIS-2
STAT-induced STAT inhibitor 2
cytokine inducible SH2-containing protein 2
cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168655.1NP_001162126.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001162126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC167222, AK137403
    Consensus CDS
    CCDS24136.1
    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Related
    ENSMUSP00000129331.2, ENSMUST00000170690.8
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  2. NM_001168656.1NP_001162127.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001162127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC167222, AK137403
    Consensus CDS
    CCDS24136.1
    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Related
    ENSMUSP00000131875.2, ENSMUST00000172070.8
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  3. NM_001168657.1NP_001162128.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001162128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC167222, AK137403
    Consensus CDS
    CCDS24136.1
    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Related
    ENSMUSP00000113378.2, ENSMUST00000119917.2
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  4. NM_007706.4NP_031732.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_031732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC167222, AK137403, BY069559
    Consensus CDS
    CCDS24136.1
    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Related
    ENSMUSP00000020215.10, ENSMUST00000020215.16
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95219765..95253176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313899.3XP_017169388.1  suppressor of cytokine signaling 2 isoform X1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. XM_017313896.3XP_017169385.1  suppressor of cytokine signaling 2 isoform X1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. XM_011243406.3XP_011241708.1  suppressor of cytokine signaling 2 isoform X2

    See identical proteins and their annotated locations for XP_011241708.1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  4. XM_017313897.2XP_017169386.1  suppressor of cytokine signaling 2 isoform X1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  5. XM_017313898.2XP_017169387.1  suppressor of cytokine signaling 2 isoform X1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  6. XM_017313900.1XP_017169389.1  suppressor of cytokine signaling 2 isoform X1

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  7. XM_030245030.2XP_030100890.1  suppressor of cytokine signaling 2 isoform X7

    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  8. XM_036155751.1XP_036011644.1  suppressor of cytokine signaling 2 isoform X7

    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  9. XM_011243410.4XP_011241712.1  suppressor of cytokine signaling 2 isoform X7

    See identical proteins and their annotated locations for XP_011241712.1

    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  10. XM_036155752.1XP_036011645.1  suppressor of cytokine signaling 2 isoform X7

    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  11. XM_036155753.1XP_036011646.1  suppressor of cytokine signaling 2 isoform X7

    UniProtKB/Swiss-Prot
    O35717
    UniProtKB/TrEMBL
    A0A6P7RDL9, Q548Q7
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  12. XM_017313902.3XP_017169391.1  suppressor of cytokine signaling 2 isoform X6

    UniProtKB/TrEMBL
    A0A8C6HCL3
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  13. XM_036155750.1XP_036011643.1  suppressor of cytokine signaling 2 isoform X5

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158198
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  14. XM_006513515.5XP_006513578.1  suppressor of cytokine signaling 2 isoform X3

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  15. XM_017313901.3XP_017169390.1  suppressor of cytokine signaling 2 isoform X4

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  16. XM_030245028.1XP_030100888.1  suppressor of cytokine signaling 2 isoform X2

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cl02533
    Location:158197
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  17. XM_006513517.5XP_006513580.1  suppressor of cytokine signaling 2 isoform X4

    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...