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F3 coagulation factor III, tissue factor [ Homo sapiens (human) ]

Gene ID: 2152, updated on 2-Nov-2024

Summary

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Official Symbol
F3provided by HGNC
Official Full Name
coagulation factor III, tissue factorprovided by HGNC
Primary source
HGNC:HGNC:3541
See related
Ensembl:ENSG00000117525 MIM:134390; AllianceGenome:HGNC:3541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF; TFA; CD142
Summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Ubiquitous expression in placenta (RPKM 54.0), gall bladder (RPKM 41.2) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
1p21.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (94529173..94541759, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (94377216..94389797, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94994729..95007315, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 29 Neighboring gene ARHGAP29 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2220 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:94792875-94793386 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 29 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94883134-94883925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1347 Neighboring gene ribosomal protein L21 pseudogene 26 Neighboring gene ATP binding cassette subfamily D member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1097 Neighboring gene uncharacterized LOC124904223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:95018439-95018940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:95018941-95019440 Neighboring gene uncharacterized LOC105378861 Neighboring gene microRNA 12133 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:95070951-95072150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:95074066-95074566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:95074567-95075067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:95090684-95091191 Neighboring gene SLC44A3 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. What is wrong with the allosteric disulfide bond hypothesis? Bach RR, et al. Arterioscler Thromb Vasc Biol, 2009 Dec. PMID 19923558
  2. Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer. Haubold K, et al. Thromb Haemost, 2009 Jun. PMID 19492160
  3. Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake. Lopez-Vilchez I, et al. Cardiovasc Res, 2009 Nov 1. PMID 19541671
  4. Increased expression of TF on monocytes, but decreased numbers of TF bearing microparticles in blood from patients with acute myocardial infarction. Keuren JF, et al. Eur J Haematol, 2009 Oct. PMID 19558505
  5. Relative contributions of collagen and tissue factor to thrombus formation on damaged vascular vessels: in-vitro studies with circulating blood. Lopez-Vilchez I, et al. Coron Artery Dis, 2009 Sep. PMID 19561489

See all (647) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.
    Title: Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.
  2. Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer.
    Title: Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer.
  3. Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19.
    Title: Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19.
  4. Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity.
    Title: Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.
  5. High CD142 Level Marks Tumor-Promoting Fibroblasts with Targeting Potential in Colorectal Cancer.
    Title: High CD142 Level Marks Tumor-Promoting Fibroblasts with Targeting Potential in Colorectal Cancer.
  6. Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.
    Title: Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.
  7. Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis.
    Title: Tissue factor expression in monocyte subsets during human immunothrombosis, endotoxemia and sepsis.
  8. CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation.
    Title: CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation.
  9. The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.
    Title: The Heparan Sulfate Proteoglycan Syndecan-1 Triggers Breast Cancer Cell-Induced Coagulability by Induced Expression of Tissue Factor.
  10. Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease.
    Title: Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease.
Submit: New GeneRIF Correction See all GeneRIFs (573)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
EBI GWAS Catalog
Genetic predictors of fibrin D-dimer levels in healthy adults.
EBI GWAS Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of coagulation factor III (F3; thromboplastin, tissue factor) in peptide-treated PBMCs PubMed
Vif vif HIV-1 Vif upregulates the expression of coagulation factor III (F3, thromboplastin, tissue factor) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ17960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of blood coagulation via clotting cascade IC
Inferred by Curator
more info
 PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of plasma proteins involved in acute inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of positive chemotaxis IC
Inferred by Curator
more info
 PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of serine-type peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tissue factor
Names
coagulation factor III (thromboplastin, tissue factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029366.1 RefSeqGene

    Range
    5099..17685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_552

mRNA and Protein(s)

  1. NM_001178096.2 → NP_001171567.1  tissue factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC093117, AF487337, DB499288
    Consensus CDS
    CCDS53345.1
    UniProtKB/TrEMBL
    Q86SE7
    Related
    ENSP00000359226.4, ENST00000370207.4
    Conserved Domains (2) summary
    pfam01108
    Location:34 → 114
    Tissue_fac; Tissue factor
    cl21522
    Location:138 → 190
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001993.5 → NP_001984.1  tissue factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093117, DB499288, M27436
    Consensus CDS
    CCDS750.1
    UniProtKB/Swiss-Prot
    D3DT47, P13726, Q6FHG2, Q86WH4
    UniProtKB/TrEMBL
    B2R6M5
    Related
    ENSP00000334145.7, ENST00000334047.12
    Conserved Domains (2) summary
    pfam01108
    Location:34 → 118
    Tissue_fac; Tissue factor
    pfam09294
    Location:138 → 242
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    94529173..94541759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    94377216..94389797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13726.1 GenPept UniProtKB/Swiss-Prot:P13726

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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