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F3 coagulation factor III, tissue factor [ Homo sapiens (human) ]

Gene ID: 2152, updated on 9-Oct-2021

Summary

Official Symbol
F3provided by HGNC
Official Full Name
coagulation factor III, tissue factorprovided by HGNC
Primary source
HGNC:HGNC:3541
See related
Ensembl:ENSG00000117525 MIM:134390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF; TFA; CD142
Summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Ubiquitous expression in placenta (RPKM 54.0), gall bladder (RPKM 41.2) and 22 other tissues See more
Orthologs
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Genomic context

Location:
1p21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (94529173..94541759, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94994729..95007315, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 26 Neighboring gene ATP binding cassette subfamily D member 3 Neighboring gene uncharacterized LOC105378861 Neighboring gene microRNA 12133 Neighboring gene SLC44A3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association search for type 2 diabetes genes in African Americans.
GeneReviews: Not available
Genetic predictors of fibrin D-dimer levels in healthy adults.
GeneReviews: Not available
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of coagulation factor III (F3; thromboplastin, tissue factor) in peptide-treated PBMCs PubMed
Vif vif HIV-1 Vif upregulates the expression of coagulation factor III (F3, thromboplastin, tissue factor) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of blood coagulation via clotting cascade IC
Inferred by Curator
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of plasma proteins involved in acute inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of positive chemotaxis IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tissue factor
Names
coagulation factor III (thromboplastin, tissue factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029366.1 RefSeqGene

    Range
    5099..17685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_552

mRNA and Protein(s)

  1. NM_001178096.2NP_001171567.1  tissue factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC093117, AF487337, DB499288
    Consensus CDS
    CCDS53345.1
    UniProtKB/Swiss-Prot
    P13726
    Related
    ENSP00000359226.4, ENST00000370207.4
    Conserved Domains (2) summary
    pfam01108
    Location:34114
    Tissue_fac; Tissue factor
    cl21522
    Location:138190
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001993.5NP_001984.1  tissue factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093117, DB499288, M27436
    Consensus CDS
    CCDS750.1
    UniProtKB/Swiss-Prot
    P13726
    Related
    ENSP00000334145.7, ENST00000334047.12
    Conserved Domains (2) summary
    pfam01108
    Location:34118
    Tissue_fac; Tissue factor
    pfam09294
    Location:138242
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    94529173..94541759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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