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Zfp609 zinc finger protein 609 [ Mus musculus (house mouse) ]

Gene ID: 214812, updated on 26-Sep-2022

Summary

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Official Symbol
Zfp609provided by MGI
Official Full Name
zinc finger protein 609provided by MGI
Primary source
MGI:MGI:2674092
See related
Ensembl:ENSMUSG00000040524 AllianceGenome:MGI:2674092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf609; mKIAA0295; 9830165N24
Summary
Enables promoter-specific chromatin binding activity. Involved in positive regulation of neuron migration; positive regulation of transcription by RNA polymerase II; and regulation of myoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brown fat; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human ZNF609 (zinc finger protein 609). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.8), CNS E14 (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp609 in Genome Data Viewer
Location:
9; 9 C
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65598860..65735004, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65691578..65827564, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 53535

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p. Wang Y, et al. Int J Biol Macromol, 2019 Jan. PMID 30201567
  2. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, et al. Mol Cell, 2017 Apr 6. PMID 28344082, Free PMC Article
  3. Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DLC, et al. Neuron, 2017 Jan 18. PMID 28041881, Free PMC Article
  4. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Reed NP, et al. Genes Immun, 2013 Jan. PMID 23076336, Free PMC Article
  5. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Costa Y, et al. Nature, 2013 Mar 21. PMID 23395962, Free PMC Article

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p
    Title: A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p.
  2. Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration.
    Title: Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration.
  3. Zfp609 is necessary for Rag1 and Rag2 expression in developing thymocytes.
    Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell differentiation in thymus TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of myoblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 609

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172536.3 → NP_766124.2  zinc finger protein 609

    See identical proteins and their annotated locations for NP_766124.2

    Status: VALIDATED

    Source sequence(s)
    AC121979, AK036715, BC016271, BC058943, BF465900
    Consensus CDS
    CCDS23297.2
    UniProtKB/Swiss-Prot
    Q6ZQE3, Q8BZ47
    Related
    ENSMUSP00000124089.2, ENSMUST00000159109.2
    Conserved Domains (2) summary
    PTZ00449
    Location:1005 → 1228
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5189
    Location:412 → 533
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65598860..65735004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154823.1 → XP_036010716.1  zinc finger protein 609 isoform X3

    Conserved Domains (1) summary
    COG5189
    Location:163 → 284
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

  2. XM_006511007.5 → XP_006511070.1  zinc finger protein 609 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:776 → 999
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5189
    Location:183 → 304
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

  3. XM_036154822.1 → XP_036010715.1  zinc finger protein 609 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:1005 → 1228
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5189
    Location:412 → 533
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ47.2 GenPept UniProtKB/Swiss-Prot:Q8BZ47

Gene LinkOut

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