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ZNF609 zinc finger protein 609 [ Homo sapiens (human) ]

Gene ID: 23060, updated on 6-Jul-2026
Official Symbol
ZNF609provided by HGNC
Official Full Name
zinc finger protein 609provided by HGNC
Primary source
HGNC:HGNC:29003
See related
Ensembl:ENSG00000180357 MIM:617474; AllianceGenome:HGNC:29003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable promoter-specific chromatin binding activity. Involved in regulation of myoblast proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in testis (RPKM 16.5), ovary (RPKM 10.7) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZNF609 in Genome Data Viewer
Location:
15q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64459578..64686068)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62269004..62495294)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64752777..64978267)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene PCNA clamp associated factor Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64831500-64832000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64832001-64832501 Neighboring gene uncharacterized LOC101930091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9571 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64849587-64850088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64850089-64850588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855291-64855860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855861-64856430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9574 Neighboring gene MPRA-validated peak2369 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64895833-64896332 Neighboring gene ribosomal protein S26 pseudogene 50 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64909826-64910418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9575 Neighboring gene ribosomal protein L21 pseudogene 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64945206-64945706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64958513-64959212 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64959213-64959910 Neighboring gene RNA, U6 small nuclear 549, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr15:64977741-64978242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64991763-64992599 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64992600-64993437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6537 Neighboring gene uncharacterized LOC124903507 Neighboring gene MPRA-validated peak2370 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65010266-65010766 Neighboring gene ornithine decarboxylase antizyme 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis. Wang J, et al. Kaohsiung J Med Sci, 2021 Aug. PMID 33943007, Free PMC Article
  2. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway. Ouyang X, et al. Mol Ther, 2023 Jun 7. PMID 36110046, Free PMC Article
  3. Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression. Liu Z, et al. Eur Rev Med Pharmacol Sci, 2019 Nov. PMID 31773689
  4. CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells. Gao J, et al. Mol Cell Endocrinol, 2024 Sep 1. PMID 38679361
  5. CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p. Zhu L, et al. Eur Rev Med Pharmacol Sci, 2019 Apr. PMID 31002133

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells.
    Title: CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells.
  2. A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
    Title: A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
  3. YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
    Title: YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
  4. CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
    Title: CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
  5. Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
    Title: Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
  6. CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
    Title: CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
  7. our current study reveals the role of the circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma.
    Title: CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma.
  8. Circular RNA circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, resulting in a protein that controls myoblast proliferation.
    Title: Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
  9. these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
    Title: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0295, MGC164858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of myoblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of myoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 609

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015042.2 → NP_055857.1  zinc finger protein 609

    See identical proteins and their annotated locations for NP_055857.1

    Status: VALIDATED

    Source sequence(s)
    AC090543, AC091231
    Consensus CDS
    CCDS32270.1
    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3
    Related
    ENSP00000316527.3, ENST00000326648.5
    Conserved Domains (2) summary
    PTZ00121
    Location:1002 → 1200
    PTZ00121; MAEBL; Provisional
    COG5189
    Location:412 → 533
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    64459578..64686068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432263.1 → XP_047288219.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3
    Related
    ENSP00000595274.1, ENST00000925215.1

  2. XM_047432265.1 → XP_047288221.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3

  3. XM_017022021.2 → XP_016877510.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3
    Conserved Domains (2) summary
    PTZ00121
    Location:1002 → 1200
    PTZ00121; MAEBL; Provisional
    COG5189
    Location:412 → 533
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

  4. XM_047432266.1 → XP_047288222.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62269004..62495294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377549.1 → XP_054233524.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3

  2. XM_054377550.1 → XP_054233525.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3

  3. XM_054377548.1 → XP_054233523.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3

  4. XM_054377551.1 → XP_054233526.1  zinc finger protein 609 isoform X1

    UniProtKB/Swiss-Prot
    O15014, Q0D2I2
    UniProtKB/TrEMBL
    A0ACI8T9D3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15014.2 GenPept UniProtKB/Swiss-Prot:O15014

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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