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Tcf7 transcription factor 7, T cell specific [ Mus musculus (house mouse) ]

Gene ID: 21414, updated on 22-Jan-2023

Summary

Official Symbol
Tcf7provided by MGI
Official Full Name
transcription factor 7, T cell specificprovided by MGI
Primary source
MGI:MGI:98507
See related
Ensembl:ENSMUSG00000000782 AllianceGenome:MGI:98507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcf1; TCF-1
Summary
This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
Expression
Biased expression in thymus adult (RPKM 829.6) and spleen adult (RPKM 56.0) See more
Orthologs
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Genomic context

See Tcf7 in Genome Data Viewer
Location:
11 B1.3; 11 31.86 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52137347..52174211, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52246527..52283383, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12206 Neighboring gene olfactory receptor family 2 subfamily Y member 6 Neighboring gene S-phase kinase-associated protein 1 Neighboring gene predicted gene, 30217 Neighboring gene voltage-dependent anion channel 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within T cell receptor V(D)J recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic hindgut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor 7
Names
T-cell-specific transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313981.1NP_001300910.1  transcription factor 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037616, AL645862, AW545274
    Consensus CDS
    CCDS24670.1
    UniProtKB/Swiss-Prot
    Q00417
    UniProtKB/TrEMBL
    Q80UF1
    Conserved Domains (2) summary
    cd01388
    Location:188258
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1100
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_009331.4NP_033357.1  transcription factor 7

    See identical proteins and their annotated locations for NP_033357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK037616, AW545274, BY095426
    Consensus CDS
    CCDS24670.1
    UniProtKB/Swiss-Prot
    Q00417
    UniProtKB/TrEMBL
    Q80UF1
    Related
    ENSMUSP00000084055.4, ENSMUST00000086844.10
    Conserved Domains (2) summary
    cd01388
    Location:188258
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1100
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    52137347..52174211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245771.2XP_030101631.1  transcription factor 7 isoform X5

    UniProtKB/TrEMBL
    A0A6P5QPN6
    Conserved Domains (2) summary
    cd01388
    Location:273343
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_030245772.2XP_030101632.1  transcription factor 7 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:273343
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_030245767.2XP_030101627.1  transcription factor 7 isoform X2

    UniProtKB/TrEMBL
    A0A6P5QMS2
    Conserved Domains (2) summary
    cd01388
    Location:273343
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_030245770.2XP_030101630.1  transcription factor 7 isoform X4

    Related
    ENSMUSP00000104699.3, ENSMUST00000109071.3
    Conserved Domains (2) summary
    cd01388
    Location:304374
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. XM_030245766.2XP_030101626.1  transcription factor 7 isoform X1

    UniProtKB/TrEMBL
    A0A6P7RGP7
    Conserved Domains (2) summary
    cd01388
    Location:304374
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. XM_030245769.2XP_030101629.1  transcription factor 7 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:304374
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:20216
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. XM_030245773.2XP_030101633.1  transcription factor 7 isoform X7

    Conserved Domains (1) summary
    cd01388
    Location:98168
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...