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TCF7 transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 6932, updated on 28-Nov-2021

Summary

Official Symbol
TCF7provided by HGNC
Official Full Name
transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:11639
See related
Ensembl:ENSG00000081059 MIM:189908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCF-1
Summary
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
Expression
Broad expression in lymph node (RPKM 9.2), appendix (RPKM 6.3) and 14 other tissues See more
Orthologs
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Genomic context

See TCF7 in Genome Data Viewer
Location:
5q31.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134114681..134148229)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133450372..133483901)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 Neighboring gene uncharacterized LOC105379185 Neighboring gene Sharpr-MPRA regulatory region 13334 Neighboring gene S-phase kinase associated protein 1 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene microRNA 3661

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36364, MGC47735

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in T cell receptor V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gamma-delta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gamma-delta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor 7
Names
T-cell-factor-7
T-cell-specific transcription factor 1
transcription factor 7 (T-cell specific, HMG-box)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030367.1 RefSeqGene

    Range
    4971..38500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134851.4NP_001128323.2  transcription factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001128323.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as A), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, HY048657, X59869, X59871
    Consensus CDS
    CCDS47263.2
    UniProtKB/Swiss-Prot
    P36402
    Related
    ENSP00000430179.1, ENST00000518915.5
    Conserved Domains (2) summary
    cd01388
    Location:154224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001346425.2NP_001333354.1  transcription factor 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate exon in the coding region, compared to variant 1. The resulting isoform (5) is longer, compared to isoform 1.
    Source sequence(s)
    AC008608, AC011336, AK057580, AL832816, BC048769, CR976030, X59870
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75
  3. NM_001346450.2NP_001333379.1  transcription factor 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, CN274309, DB128524, X59871
    UniProtKB/Swiss-Prot
    P36402
  4. NM_001366502.2NP_001353431.1  transcription factor 7 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011336, AK310591, DB137814
    Conserved Domains (2) summary
    cd01388
    Location:129199
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1272
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_003202.5NP_003193.2  transcription factor 7 isoform 1

    See identical proteins and their annotated locations for NP_003193.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC008608, AC011336, AK057580, AL832816, BC048769, X59870
    Consensus CDS
    CCDS4169.1
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75
    Related
    ENSP00000340347.5, ENST00000342854.10
    Conserved Domains (2) summary
    cd01388
    Location:269339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_201632.5NP_963963.1  transcription factor 7 isoform 2

    See identical proteins and their annotated locations for NP_963963.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as B), differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC011336, AK057580, BC048769, DB106996, X59870
    Consensus CDS
    CCDS4170.1
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75
    Related
    ENSP00000378469.1, ENST00000395023.5
    Conserved Domains (2) summary
    cd01388
    Location:154224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_201634.5NP_963965.1  transcription factor 7 isoform 4

    See identical proteins and their annotated locations for NP_963965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as C), differs in the 5' UTR, has multiple coding region differences, uses a downstream start codon, and differs in the 3' UTR, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011336, CN274309, HY048657, X59871
    Consensus CDS
    CCDS43362.1
    UniProtKB/Swiss-Prot
    P36402
    Related
    ENSP00000367822.4, ENST00000378560.8
    Conserved Domains (2) summary
    cd01388
    Location:154224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. NM_213648.5NP_998813.1  transcription factor 7 isoform 2

    See identical proteins and their annotated locations for NP_998813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, has multiple coding region differences, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC011336, AK057580, AL832816, BC048769, DB137814, DB161143, X59870
    Consensus CDS
    CCDS4170.1
    UniProtKB/Swiss-Prot
    P36402
    UniProtKB/TrEMBL
    B3KQ75
    Related
    ENSP00000429547.1, ENST00000520958.5
    Conserved Domains (2) summary
    cd01388
    Location:154224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding

RNA

  1. NR_033449.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008608, AC011336, AK057580

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134114681..134148229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714682.2XP_006714745.1  transcription factor 7 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:300370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_006714684.2XP_006714747.1  transcription factor 7 isoform X6

    UniProtKB/Swiss-Prot
    P36402
    Conserved Domains (2) summary
    cd01388
    Location:269339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_011543606.1XP_011541908.1  transcription factor 7 isoform X4

    Conserved Domains (2) summary
    cd01388
    Location:300370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_011543604.2XP_011541906.1  transcription factor 7 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:300370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. XM_006714678.3XP_006714741.1  transcription factor 7 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:300370
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. XM_006714679.3XP_006714742.1  transcription factor 7 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:269339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:20212
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. XM_006714685.4XP_006714748.1  transcription factor 7 isoform X7

    Conserved Domains (2) summary
    cd01388
    Location:185255
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. XM_006714686.4XP_006714749.1  transcription factor 7 isoform X10

    Conserved Domains (2) summary
    cd01388
    Location:154224
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:197
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. XM_011543613.3XP_011541915.1  transcription factor 7 isoform X13

    Conserved Domains (1) summary
    cd01388
    Location:67137
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  10. XM_011543608.2XP_011541910.1  transcription factor 7 isoform X9

    Conserved Domains (2) summary
    cd01388
    Location:160230
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1272
    CTNNB1_binding; N-terminal CTNNB1 binding
  11. XM_011543609.2XP_011541911.1  transcription factor 7 isoform X11

    Conserved Domains (2) summary
    cd01388
    Location:129199
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1272
    CTNNB1_binding; N-terminal CTNNB1 binding
  12. XM_011543607.2XP_011541909.1  transcription factor 7 isoform X8

    Conserved Domains (2) summary
    cd01388
    Location:181251
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:3393
    CTNNB1_binding; N-terminal CTNNB1 binding
  13. XM_017009790.1XP_016865279.1  transcription factor 7 isoform X14

RNA

  1. XR_948292.1 RNA Sequence

    Related
    ENST00000395029.5
  2. XR_001742232.1 RNA Sequence

  3. XR_001742231.1 RNA Sequence

  4. XR_948294.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134852.1: Suppressed sequence

    Description
    NM_001134852.1: This RefSeq was temporarily suppressed because the CDS may possibly be 5'-partial, and the nature of its 5' end is unclear.
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