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Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 [ Mus musculus (house mouse) ]

Gene ID: 214084, updated on 17-Sep-2019

Summary

Official Symbol
Slc18a2provided by MGI
Official Full Name
solute carrier family 18 (vesicular monoamine), member 2provided by MGI
Primary source
MGI:MGI:106677
See related
Ensembl:ENSMUSG00000025094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vmat2; 9330105E13; 1110037L13Rik
Expression
Biased expression in ovary adult (RPKM 36.9), whole brain E14.5 (RPKM 10.7) and 5 other tissues See more
Orthologs

Genomic context

See Slc18a2 in Genome Data Viewer
Location:
19 D3; 19 54.64 cM
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59260878..59296012)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (59335368..59370502)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930442E04 gene Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene VISTA enhancer mm447 Neighboring gene PDZ domain containing 8 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 33756

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC90556

Gene Ontology Provided by MGI

Function Evidence Code Pubs
amine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
monoamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serotonin:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging ISO
Inferred from Sequence Orthology
more info
 
aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aminergic neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
drug transport IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
insulin secretion ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
monoamine transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter loading into synaptic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dense core granule ISO
Inferred from Sequence Orthology
more info
 
dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of neuronal dense core vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptic vesicular amine transporter
Names
VAT2
monoamine transporter
solute carrier family 18 member 2
vesicular amine transporter 2
vesicular monoamine transporter 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172523.3NP_766111.1  synaptic vesicular amine transporter

    See identical proteins and their annotated locations for NP_766111.1

    Status: VALIDATED

    Source sequence(s)
    AC139040, AK033871, AK035644, AV328655
    Consensus CDS
    CCDS29935.1
    UniProtKB/Swiss-Prot
    Q8BRU6
    Related
    ENSMUSP00000026084.3, ENSMUST00000026084.4
    Conserved Domains (3) summary
    cd06174
    Location:297474
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00880
    Location:135276
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:133440
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p6 C57BL/6J

    Range
    59260878..59296012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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