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Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 [ Mus musculus (house mouse) ]

Gene ID: 214084, updated on 21-Apr-2024

Summary

Official Symbol
Slc18a2provided by MGI
Official Full Name
solute carrier family 18 (vesicular monoamine), member 2provided by MGI
Primary source
MGI:MGI:106677
See related
Ensembl:ENSMUSG00000025094 AllianceGenome:MGI:106677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vmat2; 9330105E13; 1110037L13Rik
Summary
Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and serotonin:sodium symporter activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within several processes, including locomotory behavior; response to amphetamine; and response to toxic substance. Located in dopaminergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; eye; integumental system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 36.9), whole brain E14.5 (RPKM 10.7) and 5 other tissues See more
Orthologs
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Genomic context

Location:
19 D3; 19 54.64 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59249310..59284444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59260878..59296012)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930442E04 gene Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene VISTA enhancer mm447 Neighboring gene PDZ domain containing 8 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 50440

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC90556

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables monoamine:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aminergic neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter loading into synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in somato-dendritic dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptic vesicular amine transporter
Names
VAT2
monoamine transporter
solute carrier family 18 member 2
vesicular amine transporter 2
vesicular monoamine transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172523.3NP_766111.1  synaptic vesicular amine transporter

    See identical proteins and their annotated locations for NP_766111.1

    Status: VALIDATED

    Source sequence(s)
    AC139040, AK033871, AK035644, AV328655
    Consensus CDS
    CCDS29935.1
    UniProtKB/Swiss-Prot
    Q8BRU6, Q8CC55
    Related
    ENSMUSP00000026084.4, ENSMUST00000026084.5
    Conserved Domains (3) summary
    cd06174
    Location:297474
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00880
    Location:135276
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:133440
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    59249310..59284444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)