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SLC18A2 solute carrier family 18 member A2 [ Homo sapiens (human) ]

Gene ID: 6571, updated on 22-Jan-2023

Summary

Official Symbol
SLC18A2provided by HGNC
Official Full Name
solute carrier family 18 member A2provided by HGNC
Primary source
HGNC:HGNC:10935
See related
Ensembl:ENSG00000165646 MIM:193001; AllianceGenome:HGNC:10935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SVAT; SVMT; VAT2; VMAT2; PKDYS2
Summary
This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
Expression
Ubiquitous expression in adrenal (RPKM 12.2), ovary (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See SLC18A2 in Genome Data Viewer
Location:
10q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (117241114..117279430)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (118135601..118173927)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119000625..119038941)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 26 Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene SLC18A2 antisense RNA 1 Neighboring gene PDZ domain containing 8 Neighboring gene CRISPRi-validated cis-regulatory element chr10.4281 Neighboring gene CRISPRi-validated cis-regulatory element chr10.4282

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 18 (vesicular monoamine), member 2 (SLC18A2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26538, MGC120477, MGC120478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monoamine transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables monoamine:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in dopamine transport TAS
Traceable Author Statement
more info
PubMed 
involved_in histamine secretion by mast cell IEA
Inferred from Electronic Annotation
more info
 
involved_in histamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in monoamine transport TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neurotransmitter loading into synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
involved_in neurotransmitter transport TAS
Traceable Author Statement
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in sequestering of neurotransmitter NAS
Non-traceable Author Statement
more info
PubMed 
involved_in serotonin secretion by mast cell IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in somato-dendritic dopamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in clathrin-sculpted monoamine transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptic vesicular amine transporter
Names
monoamine neurotransmitter transporter
solute carrier family 18 (vesicular monoamine transporter), member 2
synaptic vesicle amine transporter, brain
synaptic vesicle monoamine transporter, brain
vesicle monoamine transporter type 2
vesicle monoamine/H+ antiporter
vesicular amine transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003054.6NP_003045.2  synaptic vesicular amine transporter

    See identical proteins and their annotated locations for NP_003045.2

    Status: REVIEWED

    Source sequence(s)
    AL391988, BQ416859, DB458870, L23205
    Consensus CDS
    CCDS7599.1
    UniProtKB/Swiss-Prot
    Q05940, Q9H3P6
    Related
    ENSP00000496339.1, ENST00000644641.2
    Conserved Domains (2) summary
    TIGR00880
    Location:132273
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:130437
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    117241114..117279430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    118135601..118173927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)