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SLC18A2 solute carrier family 18 member A2 [ Homo sapiens (human) ]

Gene ID: 6571, updated on 18-Aug-2020

Summary

Official Symbol
SLC18A2provided by HGNC
Official Full Name
solute carrier family 18 member A2provided by HGNC
Primary source
HGNC:HGNC:10935
See related
Ensembl:ENSG00000165646 MIM:193001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SVAT; SVMT; VAT2; VMAT2; PKDYS2
Summary
This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
Expression
Ubiquitous expression in adrenal (RPKM 12.2), ovary (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See SLC18A2 in Genome Data Viewer
Location:
10q25.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (117241114..117279430)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119000584..119038941)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 26 Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene uncharacterized LOC105378500 Neighboring gene PDZ domain containing 8 Neighboring gene CRISPRi-validated cis-regulatory element chr10.4281 Neighboring gene CRISPRi-validated cis-regulatory element chr10.4282

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 18 (vesicular monoamine), member 2 (SLC18A2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26538, MGC120477, MGC120478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monoamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monoamine transmembrane transporter activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serotonin:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
dopamine transport TAS
Traceable Author Statement
more info
PubMed 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
monoamine transport TAS
Traceable Author Statement
more info
PubMed 
negative regulation of reactive oxygen species biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
neurotransmitter loading into synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
neurotransmitter transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
sequestering of neurotransmitter NAS
Non-traceable Author Statement
more info
PubMed 
serotonin uptake IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
clathrin-sculpted monoamine transport vesicle membrane TAS
Traceable Author Statement
more info
 
dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptic vesicular amine transporter
Names
monoamine neurotransmitter transporter
solute carrier family 18 (vesicular monoamine transporter), member 2
synaptic vesicle amine transporter, brain
synaptic vesicle monoamine transporter, brain
vesicle monoamine transporter type 2
vesicle monoamine/H+ antiporter
vesicular amine transporter 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003054.6NP_003045.2  synaptic vesicular amine transporter

    See identical proteins and their annotated locations for NP_003045.2

    Status: REVIEWED

    Source sequence(s)
    AL391988, BQ416859, DB458870, L23205
    Consensus CDS
    CCDS7599.1
    UniProtKB/Swiss-Prot
    Q05940
    Related
    ENSP00000496339.1, ENST00000644641.2
    Conserved Domains (2) summary
    TIGR00880
    Location:132273
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:130437
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    117241114..117279430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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