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Tbca tubulin cofactor A [ Mus musculus (house mouse) ]

Gene ID: 21371, updated on 8-Feb-2024

Summary

Official Symbol
Tbcaprovided by MGI
Official Full Name
tubulin cofactor Aprovided by MGI
Primary source
MGI:MGI:107549
See related
Ensembl:ENSMUSG00000042043 AllianceGenome:MGI:107549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbca13
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be located in nucleolus. Predicted to be active in microtubule cytoskeleton. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; medulla oblongata basal plate mantle layer; pons mantle layer; and spinal cord ventricular layer. Orthologous to human TBCA (tubulin folding cofactor A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 123.1), CNS E18 (RPKM 104.1) and 14 other tissues See more
Orthologs
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Genomic context

See Tbca in Genome Data Viewer
Location:
13 C3; 13 49.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (94925428..94979431)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94788920..94842923)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35311 Neighboring gene predicted gene, 32351 Neighboring gene STARR-seq mESC enhancer starr_35312 Neighboring gene predicted gene, 46389 Neighboring gene STARR-seq mESC enhancer starr_35313 Neighboring gene STARR-seq mESC enhancer starr_35314 Neighboring gene STARR-seq mESC enhancer starr_35315 Neighboring gene STARR-seq mESC enhancer starr_35319 Neighboring gene orthopedia homeobox Neighboring gene STARR-seq mESC enhancer starr_35320 Neighboring gene predicted gene, 41024 Neighboring gene WD repeat domain 41

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin-specific chaperone A
Names
CFA
TCP1-chaperonin cofactor A
co-chaperonin associated with a- & b-tubulin
cofactor A
tubulin-folding cofactor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009321.3NP_033347.1  tubulin-specific chaperone A

    See identical proteins and their annotated locations for NP_033347.1

    Status: VALIDATED

    Source sequence(s)
    AK140276, BC051475
    Consensus CDS
    CCDS26694.1
    UniProtKB/Swiss-Prot
    P48428
    UniProtKB/TrEMBL
    Q5I0U7
    Related
    ENSMUSP00000038781.6, ENSMUST00000046644.7
    Conserved Domains (1) summary
    pfam02970
    Location:993
    TBCA; Tubulin binding cofactor A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    94925428..94979431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)