Format

Send to:

Choose Destination

TBCA tubulin folding cofactor A [ Homo sapiens (human) ]

Gene ID: 6902, updated on 13-Feb-2019

Summary

Official Symbol
TBCAprovided by HGNC
Official Full Name
tubulin folding cofactor Aprovided by HGNC
Primary source
HGNC:HGNC:11579
See related
Ensembl:ENSG00000171530 MIM:610058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in adrenal (RPKM 23.9), kidney (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See TBCA in Genome Data Viewer
Location:
5q14.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (77691169..77776361, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76986995..77072185, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs262 Neighboring gene orthopedia homeobox Neighboring gene ACTB pseudogene 2 Neighboring gene TCBA and LOC101929154 interval homotypic clusters of transcription factor binding sites enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
    Post-chaperonin tubulin folding pathway, organism-specific biosystemAlpha and beta tubulin folding intermediates are formed through ATP-dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of i...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46538

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
 
protein folding TAS
Traceable Author Statement
more info
PubMed 
tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tubulin-specific chaperone A
Names
CFA
TCP1-chaperonin cofactor A
chaperonin cofactor A
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297738.1NP_001284667.1  tubulin-specific chaperone A isoform 1

    See identical proteins and their annotated locations for NP_001284667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC026717, AK300031, DC312139
    Consensus CDS
    CCDS75263.1
    UniProtKB/Swiss-Prot
    O75347
    Related
    ENSP00000306362.6, ENST00000306388.10
    Conserved Domains (1) summary
    pfam02970
    Location:984
    TBCA; Tubulin binding cofactor A
  2. NM_001297740.1NP_001284669.1  tubulin-specific chaperone A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 3' region, which results in alternate translation stop codon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC026717, DC312139, HY015414
    Consensus CDS
    CCDS78024.1
    UniProtKB/TrEMBL
    E5RIX8
    Related
    ENSP00000429288.1, ENST00000520361.5
    Conserved Domains (1) summary
    pfam02970
    Location:955
    TBCA; Tubulin binding cofactor A
  3. NM_004607.2NP_004598.1  tubulin-specific chaperone A isoform 2

    See identical proteins and their annotated locations for NP_004598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a split 3' terminal exon, which results in an alternate translation stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC018210, DB538817, DW436723
    Consensus CDS
    CCDS4040.1
    UniProtKB/Swiss-Prot
    O75347
    UniProtKB/TrEMBL
    Q6FGD7
    Related
    ENSP00000369736.4, ENST00000380377.8
    Conserved Domains (1) summary
    pfam02970
    Location:993
    TBCA; Tubulin binding cofactor A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    77691169..77776361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    77769539..77776195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center