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Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

Gene ID: 21354, updated on 10-Oct-2019

Summary

Official Symbol
Tap1provided by MGI
Official Full Name
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
Primary source
MGI:MGI:98483
See related
Ensembl:ENSMUSG00000037321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Y3; TAP; APT1; Ham1; MTP1; PSF1; ABC17; Abcb2; Ham-1; RING4; Tap-1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Broad expression in spleen adult (RPKM 66.8), thymus adult (RPKM 59.4) and 17 other tissues See more
Orthologs

Genomic context

See Tap1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34187556..34197225)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34324501..34334170)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MHC class I protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
MHC class Ib protein binding ISO
Inferred from Sequence Orthology
more info
 
MHC protein binding IEA
Inferred from Electronic Annotation
more info
 
TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
peptide antigen-transporting ATPase activity EXP
Inferred from Experiment
more info
PubMed 
contributes_to peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to peptide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
peptide-transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
tapasin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent IEA
Inferred from Electronic Annotation
more info
 
cytosol to ER transport ISO
Inferred from Sequence Orthology
more info
 
defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
peptide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide transport ISO
Inferred from Sequence Orthology
more info
 
protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
TAP complex ISO
Inferred from Sequence Orthology
more info
 
centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 

General protein information

Preferred Names
antigen peptide transporter 1
Names
ABC transporter, MHC, 1
ATP dependent transport protein family member
ATP-binding cassette sub-family B member 2
ATP-binding cassette transporter, major histocompatibility complex, 1
ATP-binding cassette, sub-family B (MDR/TAP), member 2
histocompatibility antigen modifier 1
peptide supply factor 1
peptide transporter PSF1
peptide transporter TAP1
transporter 1 ATP-binding cassette sub-family B
transporter 1, ABC (ATP binding cassette)
transporter associated with antigen processing 1
transporter, ABC, MHC, 1
transporter, ATP-binding cassette, major histocompatibility complex, 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161730.1NP_001155202.1  antigen peptide transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001155202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK152953, AK167485, AK171363
    Consensus CDS
    CCDS50072.1
    UniProtKB/TrEMBL
    Q3TBA3, Q3U6V4
    Related
    ENSMUSP00000039264.8, ENSMUST00000041633.14
    Conserved Domains (3) summary
    TIGR00958
    Location:21688
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:176398
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:440668
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_013683.2NP_038711.2  antigen peptide transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_038711.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK152953, AK162731, AK167485
    Consensus CDS
    CCDS28643.1
    UniProtKB/Swiss-Prot
    P21958
    UniProtKB/TrEMBL
    Q3U6V4
    Related
    ENSMUSP00000128401.1, ENSMUST00000170086.7
    Conserved Domains (3) summary
    TIGR00958
    Location:21716
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:176434
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:468696
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

    Range
    34187556..34197225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p6 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p6 129X1/SvJ

    Range
    436473..446150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p6 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p6 NOD/MrkTac

    Range
    499327..509001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p6 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p6 NOD/ShiLtJ

    Range
    499530..509134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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