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Cell. 1992 Dec 24;71(7):1205-14.

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.

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1
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules. We have generated mice with a disrupted TAP1 gene using embryonic stem cell technology. TAP1-deficient mice are defective in the stable assembly and intracellular transport of class I molecules and consequently show severely reduced levels of surface class I molecules. These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S. Cells from the TAP1-deficient mice are unable to present cytosolic antigens to class I-restricted cytotoxic T cells. As predicted from the near absence of class I surface expression, TAP1-deficient mice lack CD4-8+ T cells.

PMID:
1473153
[Indexed for MEDLINE]
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